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Chevall. flower essential oil (CMEO). Gas Chromatography\u2010Mass Spectrometry (GC\u2010MS) analysis allowed for the identification of 29 compounds representing 92.73% of the total oil. The major constituent was (E)\u20102\u2010Methylbut\u20102\u2010en\u20101\u2010yl methacrylate (32.62. Antioxidant activity yielded IC50 values of 566 \u00b17\u00a0\u00b5g\/mL for DPPH, 491 \u00b1 10\u00a0\u00b5g\/mL for ABTS, and an EC50 of 235 \u00b1 12\u00a0\u00b5g\/mL for FRAP. These results demonstrate significant radical scavenging and reducing potentials compared to BHT (147 \u00b12\u00a0\u00b5g \/mL for DPPH) and ascorbic acid (201 \u00b1 5\u00a0\u00b5g\/mL for ABTS). The anti\u2010inflammatory effects of CMEO were assessed through in vitro models, revealing IC50 values for BSA denaturation, heat\u2010induced, and hypotonicity\u2010induced hemolysis tests at 508.6 \u00b1 11, 456.4 \u00b1 9, and 589 \u00b17\u00a0\u00b5g\/mL, respectively. These values were compared against standards such as Diclofenac sodium (IC50 = 265.6 \u00b17\u00a0\u00b5g\/mL) and Indomethacin (IC50 = 121.3 \u00b16\u00a0\u00b5g\/mL). Molecular docking studies provided further insights into the bioactivity of \u03b2\u2010Caryophyllene, humulene, and caryophyllene oxide, which showed strong interactions with inflammatory mediators, including TNF\u2010\u03b1, COX1, COX2, and 5\u2010LOX enzymes. These findings highlight CMEO as a potential source of natural antioxidant and anti\u2010inflammatory compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71169","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:34:56Z","timestamp":1777368896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence of the Antioxidant and Anti\u2010Inflammatory Potential of Chemically Characterized\n                    <i>Cladanthus mixtus<\/i>\n                    Flower Essential Oils: Insights From In Vitro, In Vivo, and In Silico"],"prefix":"10.1002","volume":"23","author":[{"given":"Rafik","family":"El\u2010Mernissi","sequence":"first","affiliation":[{"name":"Bioactives and Environmental Health Laboratory Faculty of Sciences Moulay Ismail University  Meknes Morocco"},{"name":"Physiology and Physiopathology Team Faculty of Sciences Genomic of Human Pathologies Research Centre Mohammed V University  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoual El","family":"Menyiy","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology National Agency for Medicinal and Aromatic Plants  Taounate Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya","family":"El\u2010Mernissi","sequence":"additional","affiliation":[{"name":"Applied Chemistry Research Unit Faculty of Science and Techniques Abdelmalek Essaadi University  Tetouan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Zouhri","sequence":"additional","affiliation":[{"name":"Bioactives and Environmental Health Laboratory Faculty of Sciences Moulay Ismail University  Meknes Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u2010Assri","family":"El\u2010Mehdi","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology Environment Agri\u2010Food and Health Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Siddique","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology Tianjin University  Tianjin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef A. Bin","family":"Jardan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Badhe","sequence":"additional","affiliation":[{"name":"Swalife Biotech LTD IE Sinhgad College of Pharmacy  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssouf Ali","family":"Younous","sequence":"additional","affiliation":[{"name":"Evangelical College  N'Djamena Chad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmael M.","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science King Khalid University Abha Saudi Arabia"},{"name":"Health And Medical Research Centre (HMRC) King Khalid University Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Mana H.","family":"Alyami","sequence":"additional","affiliation":[{"name":"Naran Health Cluster  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Amhamdi","sequence":"additional","affiliation":[{"name":"Applied Chemistry Research Unit Faculty of Science and Techniques Abdelmalek Essaadi University  Tetouan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Chakir","sequence":"additional","affiliation":[{"name":"Bioactives and Environmental Health Laboratory Faculty of Sciences Moulay Ismail University  Meknes Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oualid","family":"Abboussi","sequence":"additional","affiliation":[{"name":"Physiology and Physiopathology Team Faculty of Sciences Genomic of Human Pathologies Research Centre Mohammed V University  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lhoussain","family":"Hajji","sequence":"additional","affiliation":[{"name":"Bioactives and Environmental Health Laboratory Faculty of Sciences Moulay Ismail University  Meknes Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803269-5.00002-4"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040901"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.09.006"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15129252"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.106"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.33263\/BRIAC114.1144011457"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/23818107.2017.1395766"},{"key":"e_1_2_13_10_1","first-page":"133","article-title":"Intraspecific Variability of the Essential Oil of Cladanthus mixtus From Morocco","volume":"9","author":"Elouaddari A.","year":"2014","journal-title":"Natural Products Communications"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/22297928.2019.1682665"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11746-009-1483-3"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.32859\/era.22.48.1-19"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1596100"},{"key":"e_1_2_13_15_1","first-page":"49","article-title":"In Vivo Anti\u2010Nociceptive and Anti\u2010Inflammatory Properties of Ormenis Mixta L. fom Morocco","volume":"8","author":"Hajjaj G.","year":"2016","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/compounds3020028"},{"key":"e_1_2_13_17_1","unstructured":"Council of Europe.European Pharmacopoeia(5th ed). 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