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However, the antihepatic fibrosis activity of\n                    <jats:italic>F. tikoua<\/jats:italic>\n                    and its active constituents remain unclear. In this study, a 75% ethanol extract of\n                    <jats:italic>F. tikoua<\/jats:italic>\n                    (FT\u2010D12) was prepared and evaluated for antihepatic fibrosis effects using both in vitro and in vivo models. FT\u2010D12 dose\u2010dependently decreased the expression of fibrosis markers (FN, Collagen I, \u03b1\u2010SMA). In mice, it significantly lowered serum levels of AST, ALT, HYP, hepatic levels of PC\u2010III, COL IV, HA, and protein expression of \u03b1\u2010SMA and FN. UPLC\u2010MS\/MS analysis elucidated 39 components in FT\u2010D12, including 30 flavonoids. Network pharmacology screening highlighted apigenin\u20107\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glucoside, quercetin, icariin, syringetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glucoside, rutin, isorhamnetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glucoside, and kievitone as potential antifibrotic candidates. Quercetin showed the strongest inhibitory effect on Collagen I and FN. Further investigation suggested its antifibrotic mechanism may involve modulation of the EGFR\u2010AKT pathway. These findings provide insight into the anti\u2010hepatic fibrosis properties of\n                    <jats:italic>F. tikoua<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71191","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:30:46Z","timestamp":1775802646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["UPLC\u2010MS\/MS\u2010Network Pharmacology and Experimental Validation Reveal Active Components of\n                    <i>Ficus tikoua<\/i>\n                    for Ameliorating Liver Fibrosis"],"prefix":"10.1002","volume":"23","author":[{"given":"Shi\u2010Ying","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou Medical University  Guian New District Guizhou China"},{"name":"Engineering Research Center For the Prevention and Treatment of Chronic Diseases By Authentic Medicinal Materials Guizhou Provincial Department of Education  Guian New District Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou Medical University  Guian New District Guizhou China"},{"name":"Engineering Research Center For the Prevention and Treatment of Chronic Diseases By Authentic Medicinal Materials Guizhou Provincial Department of Education  Guian New District Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Fu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou Medical University  Guian New District Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ling\u2010ling","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou Medical University  Guian New District Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin\u2010Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou Medical University  Guian New District Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Li","family":"Ao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou Medical University  Guian New District Guizhou China"},{"name":"Engineering Research Center For the Prevention and Treatment of Chronic Diseases By Authentic Medicinal Materials Guizhou Provincial Department of Education  Guian New District Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang\u2010Gao","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; School of Pharmaceutical Sciences Guizhou Medical University  Guian New District Guizhou China"},{"name":"Engineering Research Center For the Prevention and Treatment of Chronic Diseases By Authentic Medicinal Materials Guizhou Provincial Department of Education  Guian New District Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine &amp; 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