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In this study, 1,2,3\u2010triazole\u2010based isonicotinate and nicotinate derivatives (3a\u2013c and 4a\u2013c) were synthesized via click chemistry followed by esterification, and were characterized using FT\u2010IR,\n                    <jats:sup>1<\/jats:sup>\n                    H\/\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and elemental analysis. The synthesized compounds were evaluated for their inhibitory activities against AChE, BChE, and \u03b1\u2010amylase, as well as their antioxidant potential using DPPH and ABTS radical scavenging assays. Compound 3c showed the strongest AChE inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 12.67\u00b10.66\u00a0\u00b5M), while 3a exhibited the highest BChE inhibitory activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 14.59\u00b10.048 \u00b5M). Compound 4c, a 1,2,3\u2010triazole nicotinate derivative, demonstrated good activity against AChE (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 10.08\u00b10.12\u00a0\u00b5M), BChE (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 6.51\u00b10.052\u00a0\u00b5M), and \u03b1\u2010amylase (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 7.76\u00b10.09\u00a0\u00b5M), outperforming standard inhibitors. Compound 3c exhibited very good antioxidant activity using DPPH and ABTS radical scavenging tests. Molecular docking studies supported the experimental findings, demonstrating appropriate binding energies and essential hydrogen bonds and \u03c0\u2013\u03c0 interactions at the active sites of the target enzymes. Computerized ADME analysis showed promising pharmacokinetic properties, including high gastrointestinal absorption and blood\u2010brain barrier permeability.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71202","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:51:26Z","timestamp":1775800286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["1,2,3\u2010Triazole Isonicotinate\/Nicotinate Derivatives as Cholinesterase and \u03b1\u2010Amylase Inhibitors: Synthesis, Enzyme Inhibition, Antioxidant Activity, and Molecular Docking Studies"],"prefix":"10.1002","volume":"23","author":[{"given":"Fatma","family":"\u00c7al\u0131\u015f\u0131r","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kahramanmaras Sutcu Imam University  Kahramanmaras T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Mustafa","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kahramanmaras Sutcu Imam University  Kahramanmaras T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kahramanmaras Sutcu Imam University  Kahramanmaras T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyit Ali","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kahramanmaras Sutcu Imam University  Kahramanmaras T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2025.2490060"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131079"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1070\/RC2005v074n04ABEH000893"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.01.063"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.12.095"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800149m"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064\u2010016\u20102052\u20105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijper.51.3.72"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.11.030"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3184\/174751916X14762037909434"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010013\u20100762\u20106"},{"key":"e_1_2_8_13_1","first-page":"2114","article-title":"Synthesis, Characterization and Antibacterial Activity Studies on some Fluorine Containing Quinoline\u20104\u2010carboxylic Acids and Their Derivatives","volume":"44","author":"Holla B. 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