{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:27:48Z","timestamp":1790508468395,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three new mimosin\u2010type homoisoflavonoids (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    ) and a new sappanin\u2010type homoisoflavonoid (\n                    <jats:bold>5<\/jats:bold>\n                    ), together with eight known homoisoflavonoids, were isolated from the methanol extract of the twigs and leaves of\n                    <jats:italic>Pterolobium macropterum<\/jats:italic>\n                    . Compound\n                    <jats:bold>1<\/jats:bold>\n                    is a rare tetranor\u2010homoisoflavonoid. The structures of all isolates were elucidated by comprehensive spectroscopic interpretation. The anti\u2010proliferative activity against JIMT\u20101 cells and the antibacterial activity against methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA003),\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    , and\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    of compounds\n                    <jats:bold>1\u201012<\/jats:bold>\n                    were evaluated. As a result, compound\n                    <jats:bold>2<\/jats:bold>\n                    showed excellent anti\u2010proliferative activity against JIMT\u20101 cells with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 1.08 \u00b5M, and potently inhibited the colony formation of JIMT\u20101 cells at 2.0 \u00b5M. Furthermore, compounds\n                    <jats:bold>11<\/jats:bold>\n                    and\n                    <jats:bold>12<\/jats:bold>\n                    (MIC = 32 \u00b5g\/mL) exhibited broad\u2010spectrum antibacterial activity against the abovementioned bacterial strains by regulating the ROS level. Preliminary structure\u2013activity relationship (SAR) analysis of these homoisoflavonoids revealed that the\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010unsaturated moieties are crucial for both anti\u2010proliferative and antibacterial activities.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71207","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:02:53Z","timestamp":1775800973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolation, Structural Elucidation, and Biological Evaluation of Homoisoflavonoids From\n                    <i>Pterolobium Macropterum<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"De\u2010Mei","family":"Yang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0279-9058","authenticated-orcid":false,"given":"Zhao\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-4197","authenticated-orcid":false,"given":"Rui","family":"Zhan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yunnan Normal University  Kunming P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Agronomy and Biological Science Dehong Normal University  Mangshi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052735"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00932"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101395069"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659\u2010024\u201000450\u20102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.548813"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.998217"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113343"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.11.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2024.2387307"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/np500476h"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.19.47"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2024.06.008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c00354"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2022.105279"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2010.06.016"},{"key":"e_1_2_7_17_1","unstructured":"G.\u2010P.Li \u201cStudy on Chemical Constituents and Biological Activities of Two Fabaceae Plants from Yunnan\u201d (Master's thesis Yunnan Normal University 2026). ."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600\u2010019\u201002736\u20101"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2015.1096269"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.54.1193"},{"key":"e_1_2_7_21_1","first-page":"443","article-title":"Syntheses of Two Derivatives of Chromanone","volume":"71","author":"Shan S.","year":"2008","journal-title":"Chemistry"},{"key":"e_1_2_7_22_1","first-page":"2105","article-title":"Chemical Constituents and Antibacterial Activity Contained in Caesalpinia millettii","volume":"37","author":"Chen P.","year":"2012","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/np3003673"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c00378"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118327"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2023.117544"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108578"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71207","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:48:11Z","timestamp":1785340091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/cbdv.71207"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71207","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71207"}}