{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:04:09Z","timestamp":1785341049851,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study aimed to investigate the phytochemical and biological screening of\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    L. aerial parts and roots. Extracts were obtained by maceration using solvents of increasing polarity (chloroform, ethyl acetate, and methanol). HPLC\u2010MS\/MS analysis led to the identification of 26 phenolic compounds, with hyperoside followed by delphinidin\u20103,5\u2010diglucoside and isoquercitrin identified as the main constituents of the aerial parts methanolic extract. The total phenolic and flavonoid contents varied in the range of 54.39\u2013144.09\u00a0mg GAE\/g and 16.47\u201365.19\u00a0mg RE\/g, respectively. The phosphomolybdenum assay yielded a total antioxidant capacity of 1.64\u20133.40\u00a0mmol TE\/g. The ability of the extracts to neutralize free radicals ranged between 45.27 and 171.00\u00a0mg TE\/g for DPPH and 94.51 to 454.14\u00a0mg TE\/g for ABTS assays. Furthermore, the reducing power assays, evinced that the extracts display significant activity with values ranging from 58.48 to 291.61\u00a0mg TE\/g (FRAP) and 110.12 to 472.24\u00a0mg TE\/g (CUPRAC). Moreover,\n                    <jats:italic>G. glabra<\/jats:italic>\n                    L. exhibited notable inhibitory effects against several enzymes (acetylcholinesterase, butyrylcholinesterase, \u03b1\u2010tyrosinase, \u03b1\u2010glucosidase, and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase). Overall, the obtained results provide scientific evidence supporting the traditional use of the plant and suggest its potential as a promising source of bioactive compounds for further pharmacological investigation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71208","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:12:52Z","timestamp":1776244372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HPLC\u2010MS\/MS Profiling and Evaluation of Antioxidant and Enzyme Inhibitory Activities of\n                    <i>Glycyrrhiza glabra<\/i>\n                    L. Crude Extracts"],"prefix":"10.1002","volume":"23","author":[{"given":"Hekmat B.","family":"AL\u2010Hmadi","sequence":"first","affiliation":[{"name":"Department of Biochemistry College of Medicine Al\u2010Muthanna University  Samawah Iraq"},{"name":"Department of Pharmaceutical Chemistry College of Pharmacy AL\u2010Muthanna University  Samawah Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u00effa","family":"Debbabi","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Chemistry and Clean Processes\u2010LR21ES04 Faculty of Sciences University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwar","family":"Majdoub","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Chemistry and Clean Processes\u2010LR21ES04 Faculty of Sciences University of Monastir  Monastir 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