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Their structures were established through comprehensive spectroscopic analysis, with the absolute configurations of\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    being further confirmed by electronic circular dichroism (ECD) calculations. The isolation of sesquiterpenoids and lignans aligns with the characteristic metabolites of the genus\u00a0\n                    <jats:italic>Magnolia<\/jats:italic>\n                    . Notably,\u00a0the hydroperoxy group in compound\u00a0\n                    <jats:bold>1<\/jats:bold>\n                    \u00a0and the chlorinated diphenyl ethers\u00a0\n                    <jats:bold>4<\/jats:bold>\n                    \u00a0and\u00a0\n                    <jats:bold>6<\/jats:bold>\n                    , together with 15 known compounds, are all reported for the first time from\u00a0\n                    <jats:italic>Magnolia<\/jats:italic>\n                    , highlighting the chemodiversity of this species and serving as potential chemotaxonomic markers. In biological assays, compounds\n                    <jats:bold>10<\/jats:bold>\n                    ,\n                    <jats:bold>11<\/jats:bold>\n                    ,\n                    <jats:bold>15<\/jats:bold>\n                    , and\n                    <jats:bold>19<\/jats:bold>\n                    exhibited weak cytotoxicity against HepG2 human hepatocellular carcinoma cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 20.99 to 29.07 \u00b5M, while no activity was observed against A549 and HeLa cell lines. None of the tested compounds demonstrated anti\u2010inflammatory activity in LPS\u2010stimulated RAW264.7 macrophages at concentrations up to 20.00 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71228","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:25:50Z","timestamp":1777040750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Constituents of the Twigs and Leaves of\n                    <i>Magnolia liliifera<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Jiayou","family":"Wang","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical Sciences Chongqing University  Chongqing People's Republic of China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Mei","family":"Bai","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong People's Republic of China"},{"name":"Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai People's Republic of China"},{"name":"University of Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Miao","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-0369","authenticated-orcid":false,"given":"Chuan\u2010Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong People's Republic of China"},{"name":"Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai People's Republic of China"},{"name":"University of Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Royal Botanic Gardens Kew.Magnolia Plum. 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