{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:59:41Z","timestamp":1785085181010,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lichens are an underexplored reservoir of nutritionally and pharmacologically relevant metabolites. This study provides one of the first comprehensive multivariate profiles of five ethnobotanically important lichen species (\n                    <jats:italic>Lobaria retigera, Dirinaria consimilis, Parmotrema austrosinense, Ramalina conduplicans, and Usnea orientalis<\/jats:italic>\n                    ) from Uttarakhand, India, using an integrated screening approach to evaluate and rank their bioactive potential.\u00a0A combined analysis of nutritional components (protein, carbohydrates, and essential minerals), phytochemicals (total phenolic and flavonoid content),\u00a0preliminary antioxidant screening (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl radical scavenging assay), and metabolite profiling (gas chromatography\u2010mass spectrometry) was performed. Our results\u00a0ranked and objectively identified\n                    <jats:italic>P. austrosinense<\/jats:italic>\n                    as the\u00a0most promising lead species, exhibiting the highest total phenolic content (14.08 \u00b1 2.53\u00a0mg gallic acid equivalents\/g), flavonoid content (1.80 \u00b1 0.23\u00a0mg catechin equivalents\/g), protein content (24.36 \u00b1 1.30\u00a0mg\/g), and the most effective\u00a0DPPH radical scavenging activity (83.05% inhibition). Although based solely on in vitro DPPH data, this screening establishes a prioritized ranking for further validation. Principal Component Analysis confirmed that these antioxidant traits were strongly intercorrelated.\u00a0This integrated metabolomic screening approach establishes a robust chemotaxonomic and nutritional ranking, highlighting\n                    <jats:italic>P. austrosinense<\/jats:italic>\n                    as a prime candidate for subsequent in\u2010depth investigations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71264","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T18:55:08Z","timestamp":1778439308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multivariate Chemoprospecting of Five Ethnobotanically Important Himalayan Lichens Identifies\n                    <i>Parmotrema austrosinense<\/i>\n                    as a Promising Source of Phenolic Antioxidants"],"prefix":"10.1002","volume":"23","author":[{"given":"Stuti","family":"Rawat","sequence":"first","affiliation":[{"name":"Department of Biosciences Himachal Pradesh University  Shimla India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-2029","authenticated-orcid":false,"given":"Nitesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biosciences Himachal Pradesh University  Shimla India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Quyoom","sequence":"additional","affiliation":[{"name":"Department of Botany University of Kashmir  Srinagar J&amp;K India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manzoor ul","family":"Haq","sequence":"additional","affiliation":[{"name":"Department of Botany University of Kashmir  Srinagar J&amp;K India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-512X","authenticated-orcid":false,"given":"Latif Ahmad","family":"Peer","sequence":"additional","affiliation":[{"name":"Department of Botany University of Kashmir  Srinagar J&amp;K India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11081199"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104283"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foohum.2023.11.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1663\/0013\u20100001(2005)059[0269:CAEUOL]2.0.CO;2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16814-8_2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668\u2010023\u201000489\u20106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1488"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13199\u2010019\u201000630\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.116425"},{"key":"e_1_2_10_11_1","first-page":"70","article-title":"Antioxidant Activity of Lichen Parmotrema Austrosinense and Its Antimicrobial Effect on Selected Plant Pathogens","volume":"1","author":"Rajaram S. 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