{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:00:39Z","timestamp":1785081639616,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460696"],"award-info":[{"award-number":["82460696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Three new cuevaenes, designated cuevaenes F\u2013H (\n 1<\/jats:bold>\n \u2013\n 3<\/jats:bold>\n ), together with four known analogues (\n 4<\/jats:bold>\n \u2013\n 7<\/jats:bold>\n ), were isolated from the marine\u2010derived strain\n Streptomyces malaysiensis<\/jats:italic>\n HNM0561. Their structures and absolute configurations were elucidated using HR\u2010ESIMS, extensive 1D and 2D NMR spectroscopy, and ECD calculations. Notably, this study establishes the absolute configurations of previously reported cuevaenes (\n 4<\/jats:bold>\n ,\n 5<\/jats:bold>\n , and\n 7<\/jats:bold>\n ) for the first time. Compounds\n 1<\/jats:bold>\n and\n 2<\/jats:bold>\n are distinguished by a rare chlorine substitution at C\u201017, representing a novel structural motif within the cuevaene family. Additionally, compounds\n 1<\/jats:bold>\n \u2013\n 6<\/jats:bold>\n were derivatized via esterification with (trimethylsilyl)diazomethane (TMSCHN\n 2<\/jats:sub>\n ) to afford the corresponding methyl esters (\n 1a<\/jats:bold>\n \u2013\n 6a<\/jats:bold>\n ). All isolated and derivatized compounds (\n 1<\/jats:bold>\n \u2013\n 7<\/jats:bold>\n and\n 1a<\/jats:bold>\n \u2013\n 6a<\/jats:bold>\n ) were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)\u2010activated BV2 microglial cells. Among them, compounds\n 3<\/jats:bold>\n and\n 4a<\/jats:bold>\n exhibited significant inhibitory activity, reducing NO production by 54% and 47% at a concentration of 20 \u00b5M, respectively.\n <\/jats:p>","DOI":"10.1002\/cbdv.71279","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:06:15Z","timestamp":1778353575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cuevaenes F\u2013H, Including Two Rare Chlorinated Cuevaenes From the Marine\u2010Derived\n Streptomyces malaysiensis<\/i>\n HNM0561"],"prefix":"10.1002","volume":"23","author":[{"given":"Yan\u2010Ping","family":"Huang","sequence":"first","affiliation":[{"name":"School of Life and Health Sciences Hainan International One Health Institute Hainan University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Fang","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangdong Corps Hospital Chinese People's Armed Police Force Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Wei","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences Hainan International One Health Institute Hainan University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen\u2010Hao","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences Hainan International One Health Institute Hainan University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guilin Medical University Guilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Long","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences Hainan International One Health Institute Hainan University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8372-6670","authenticated-orcid":false,"given":"Zhong\u2010Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Key Laboratory of Tropical Biological Resources of Ministry of Education Hainan University Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province Hainan Normal University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17050249"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2021.126708"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md22010051"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.53.415"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.10.82"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol802611w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2010.06.133"},{"key":"e_1_2_9_9_1","first-page":"1468","article-title":"Identification and Characterization of the Cuevaene A Biosynthetic Gene Cluster in Streptomyces sp. 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