{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:00:41Z","timestamp":1785081641929,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of Cu\u2013N\u2010heterocyclic carbene (Cu\u2013NHC) complexes (\n                    <jats:bold>3a\u2013e<\/jats:bold>\n                    ) was successfully synthesized and their structures verified by NMR, HRMS, and elemental analysis. These complexes displayed excellent catalytic performance in the 1,3\u2010dipolar cycloaddition of alkynes with azides, producing 1,4\u2010disubstituted triazoles (\n                    <jats:bold>4a\u2013e<\/jats:bold>\n                    ) in isolated yields of 80%\u201391%. The cycloaddition between phenylacetylene and various azides was also explored theoretically using DFT\/B3LYP\/6\u2010311+G(d) methods. The cytotoxic properties of the obtained compounds were evaluated against A549, HCT116, and BEAS\u20102B cell lines, with several derivatives exhibiting significant anticancer activity. Moreover, their antioxidant potential was assessed through DPPH and ABTS radical\u2010scavenging assays, in which compound\n                    <jats:bold>2<\/jats:bold>\n                    showed particularly strong performance.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71280","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T18:56:22Z","timestamp":1778439382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficient One\u2010Pot Copper(I)\u2010Catalyzed Azide\u2013Alkyne Cycloaddition in Water: Triazole Synthesis, Catalytic Applications, DFT Studies, and Biological Evaluation"],"prefix":"10.1002","volume":"23","author":[{"given":"Mohamed Oussama","family":"Zouaghi","sequence":"first","affiliation":[{"name":"Laboratory of Characterizations Applications &amp; Modeling of Materials (LR18ES08) Department of Chemistry Faculty of Sciences of Tunis University of Tunis El Manar  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takoua","family":"bouabidi","sequence":"additional","affiliation":[{"name":"Research Laboratory of Environmental Sciences and Technologies (LR16ES09) Higher Institute of Environmental Sciences and Technology University of Carthage  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedra","family":"Touj","sequence":"additional","affiliation":[{"name":"Research Laboratory of Environmental Sciences and Technologies (LR16ES09) Higher Institute of Environmental Sciences and Technology University of Carthage  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University  Malatya Turkey"},{"name":"Drug Application and Research Center \u0130n\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"Gurbuz","sequence":"additional","affiliation":[{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University  Malatya Turkey"},{"name":"Drug Application and Research Center \u0130n\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arfaoui","family":"Youssef","sequence":"additional","affiliation":[{"name":"Laboratory of Characterizations Applications &amp; 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