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(Salicaceae) is a South American medicinal plant traditionally used for the treatment of inflammatory conditions, pain, and wound healing, with its biological activity mainly attributed to clerodane diterpenes and flavonoids. This study assessed its therapeutic potential in wound repair and pain modulation by integrating patent landscaping with scientific evidence. A systematic search was conducted in the Orbit\u2010Questel database to identify relevant patent families, complemented by a literature review in PubMed, Scopus, and Web of Science. Patents and studies reporting analgesic, anti\u2010inflammatory, or wound\u2010healing activities were included. Of the 41 patent documents retrieved, eight met the inclusion criteria and were classified into three main technological strategies: (i) nanostructured sprays and biofilms containing glycolic extracts of\n                    <jats:italic>C. sylvestris<\/jats:italic>\n                    ; (ii) synergistic herbal combinations; and (iii) innovative formulations for oral mucositis. Some patents also described the isolation of clerodane diterpenes with cytomodulatory and antitumor properties. Among 51 screened scientific articles, seven were included, providing generally supportive but heterogeneous evidence. Despite its promising potential, limitations related to chemical standardization, methodological variability, and the lack of clinical and mechanistic studies remain, highlighting the need for further research to enable safe and effective therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71292","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:19:36Z","timestamp":1778696376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the Technological and Pharmacological Landscape of\n                    <i>Casearia sylvestris<\/i>\n                    : An Evidence\u2010Based Prospection for Wound Healing and Pain Management"],"prefix":"10.1002","volume":"23","author":[{"given":"Luiza Gon\u00e7alves","family":"Soutier","sequence":"first","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Federal do Paran\u00e1 \u2010 UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmim Parisotto de Souza","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Federal do Paran\u00e1 \u2010 UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-1086","authenticated-orcid":false,"given":"Carla Suelen","family":"Gurski","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Paran\u00e1 \u2010 UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Paran\u00e1 \u2010 UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Brand\u00e3o","family":"Reolon","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Estadual do Centro Oeste \u2010 UNICENTRO  Guarapuava Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7049-4363","authenticated-orcid":false,"given":"Roberto","family":"Pontarolo","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Federal do Paran\u00e1 \u2010 UFPR  Curitiba Brazil"},{"name":"Departamento De Farm\u00e1cia Universidade Estadual do Centro Oeste \u2010 UNICENTRO  Guarapuava Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Henrique Marcondes","family":"Sari","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Paran\u00e1 \u2010 UFPR  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Blum","family":"Vestena","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Estadual do Centro Oeste \u2010 UNICENTRO  Guarapuava Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weber Cl\u00e1udio Francisco Nunes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Estadual do Centro Oeste \u2010 UNICENTRO  Guarapuava Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Sartori","family":"Bonini","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Estadual do Centro Oeste \u2010 UNICENTRO  Guarapuava Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Mota","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento De Farm\u00e1cia Universidade Federal do Paran\u00e1 \u2010 UFPR  Curitiba Brazil"},{"name":"Departamento De Farm\u00e1cia Universidade Estadual do Centro Oeste \u2010 UNICENTRO  Guarapuava Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"341","volume-title":"Advances in Surgical and Medical Specialties","author":"Wilkinson H. 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