{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:00:41Z","timestamp":1785081641156,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lavender is a globally recognized herb that possesses ornamental, industrial, and medicinal value. Although extensive research has focused on its essential oils, the residual plant material remaining after oil extraction has received comparatively little attention. The ethanol precipitate (EP) from the aqueous extract of de\u2010oiled lavender was investigated on the hypnotic effect and mechanism for the first time. The results showed that EP at the dosage of 120\u00a0mg\/kg treatment reduces the locomotor activity in the open field test, prolonged pentobarbital\u2010induced sleep duration in a PCPA\u2010induced insomnia mouse model, increased 5\u2010HT levels in serum and brain regions (cortex, hippocampus, hypothalamus), and elevated the content of GABA, upregulated GAD67 and downregulated both the GABAA \u03b11 subunit and GAT\u20101 in these three brain areas which was predicted by the UPLC\u2010MS data analysis and network pharmacology, and the potentially pharmacological substance of phenolics and flavonoids. The present data suggested that the aqueous extract of de\u2010oiled lavender exerts the hypnotic effect through a GABAergic system in mice and brought substantial evidence for its extensive application and development in the future.<\/jats:p>","DOI":"10.1002\/cbdv.71307","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T18:59:24Z","timestamp":1778439564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Aqueous Extract of De\u2010Oiled Lavender Exerts Hypnotic Effect Through the GABAergic System in Mice"],"prefix":"10.1002","volume":"23","author":[{"given":"Zhiqiang","family":"Huang","sequence":"first","affiliation":[{"name":"School of Pharmacy Inner Mongolia Medical University Hohhot China"},{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Inner Mongolia Medical University Hohhot China"},{"name":"Beijing Research Institute of Chinese Medicine Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7479-624X","authenticated-orcid":false,"given":"Dingqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Research and Development Center Amway (China) R&amp;D Center Co., Ltd. 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