{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:00:40Z","timestamp":1785081640471,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The Solanaceae family, particularly the genus\n                    <jats:italic>Physalis<\/jats:italic>\n                    , is a rich source of anticancer bioactive compounds. This study first reports the chemical composition of essential oils (EOs) obtained from fruits (FO), leaves (LO), and a leaf\u2010fruit mixture (LFO) of\n                    <jats:italic>Physalis acutifolia<\/jats:italic>\n                    using gas chromatography\u2010mass spectrometry. Major components include hexadecanoic acid (36.51% in LO), phytol (32.54% in LFO), and heptacosane (31.37% in FO). Cytotoxic activity was assessed against four human cancer cell lines: A375 (malignant melanoma), T98G (glioblastoma multiforme), MDA\u2010MB\u2010231 (breast adenocarcinoma), and HCT116 (colon carcinoma). LO exhibited potent antiproliferative effects on A375 (IC50 = 9.06\u00a0\u00b5g\/mL). Molecular docking simulations suggest that hexadecanoic acid may activate peroxisome proliferator\u2010activated receptor alpha (PPAR\u03b1), while homosalate shows a high\u2010affinity binding to platelet\u2010derived growth factor receptor alpha (PDGFRA). Absorption, distribution, metabolism, and excretion (ADME) predictions indicate drug\u2010like properties for ar\u2010turmerol. These findings highlight the anticancer potential of\u00a0\n                    <jats:italic>P. acutifolia<\/jats:italic>\n                    \u00a0EOs as candidates for future pharmaceutical examination.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71312","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:14:13Z","timestamp":1778354053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First GC\/MS Profiling and Cytotoxic Evaluation of\n                    <i>Physalis acutifolia<\/i>\n                    (Solanaceae) Essential Oils: Insights From Molecular Docking and ADME Predictions"],"prefix":"10.1002","volume":"23","author":[{"given":"Sara","family":"Boussaha","sequence":"first","affiliation":[{"name":"Unit\u00e9 De Recherche: Valorisation des Ressources Naturelles Mol\u00e9cules Bioactives et Analyses Physicochimiques Et Biologiques Universit\u00e9 Fr\u00e8res Mentouri  Constantine Algeria"},{"name":"Biotechnology Laboratory \u00c9cole Nationale Sup\u00e9rieure De Biotechnologie de Constantine Nouveau P\u00f4le Universitaire Ali Mendjeli  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed B.","family":"Abdelwahab","sequence":"additional","affiliation":[{"name":"Temisis Therapeutics  Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bramucci","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Quassinti","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khellaf","family":"Rebbas","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Sciences University Mohamed Boudiaf of M'Sila  M'sila Algeria"},{"name":"Agro\u2010Biotechnology and Nutrition Laboratory in Arid and Semi\u2010Arid Zones Ibn Khaldoun University  Tiaret Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Maggi","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino  Camerino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"a121","article-title":"Recognising the Impact of Traditional Herbal Medicine in Managing Cancer: The South African Context","volume":"5","author":"Xego S.","year":"2021","journal-title":"J Med Plants Econ Dev"},{"key":"e_1_2_10_3_1","article-title":"The Therapeutic Potential of Essential Oils in Cancer Treatment: A Comprehensive Review","volume":"1","author":"Ribeiro Junior H. 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