{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:00:40Z","timestamp":1785081640869,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rengyolone, a cyclohexylethanol derivative isolated from\n                    <jats:italic>Incarvillea mairei<\/jats:italic>\n                    (Bignoniaceae), exhibited a potent anti\u2010inflammatory effect in LPS\u2010stimulated BV\u20102 cells by inhibiting the release of the inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ), as well as downregulating the levels of pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106) and elevating the level of the anti\u2010inflammatory cytokine IL\u201010. Further investigation revealed that rengyolone exerts its anti\u2010inflammatory effect in microglia by suppressing the protein expression of inducible NO synthase (iNOS) and cyclooxygenase\u20102 (COX\u20102), as well as by blocking the TLR4\/NF\u2010\u03baB signaling pathway. These results suggest that rengyolone may be a promising lead compound for the treatment of neuroinflammation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71314","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:57:26Z","timestamp":1778655446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural Product Rengyolone Attenuates LPS\u2010Induced Microglia Inflammation via Suppression of the TLR4\/NF\u2010\u03baB Pathway"],"prefix":"10.1002","volume":"23","author":[{"given":"Zhao\u2010Ting","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University  Kunming China"},{"name":"School of Pharmacy Naval Medical University  Shanghai 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