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Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    represent the first dimeric\n                    <jats:italic>Gelsemium<\/jats:italic>\n                    alkaloids composed of a humantenine\u2010type unit and a gelsedine\u2010type unit, connected through a carbonyl\u2010derived urea bridge. Compounds\n                    <jats:bold>3\u20136<\/jats:bold>\n                    were new dimeric monoterpenoid indole alkaloids featuring distinct dimerization patterns, including a carbonyl\u2010derived urea bridge (\n                    <jats:bold>3<\/jats:bold>\n                    ), azo linkages (\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    ), and a symmetric C\u2013C\u2010linked dimer (\n                    <jats:bold>6<\/jats:bold>\n                    ). Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, including NMR, single\u2010crystal X\u2010ray diffraction, and quantum\u2010chemical ECD calculations. Among the isolates, compounds\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>5<\/jats:bold>\n                    , and\n                    <jats:bold>8<\/jats:bold>\n                    exhibited significant\n                    <jats:italic>in vitro<\/jats:italic>\n                    anti\u2010herpes simplex virus type 1 (HSV\u20101) activity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.01 \u00b1 0.78, 12.55 \u00b1 1.47, and 6.35 \u00b1 0.36\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M, respectively. A preliminary structure\u2013activity relationship analysis of compounds\n                    <jats:bold>1\u201312<\/jats:bold>\n                    was also discussed.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71324","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T17:25:14Z","timestamp":1779038714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Six New Dimeric Monoterpenoid Indole Alkaloids With Antiviral Activity From\n                    <i>Gelsemium elegans<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-7794","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou P. 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