{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:00:42Z","timestamp":1785081642341,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Piper mollicomum<\/jats:italic>\n                    Kunth., a plant traditionally used in rural Brazilian communities since the colonial period, shows promising potential for cancer treatment. This study investigated the phytochemical composition and cytotoxic activity of ethanolic, dichloromethane extracts, and essential oil from the plant's leaves. Chemical analyses, including phytochemical screening, UPLC, and GC\u2013MS, were performed. Cytotoxicity was then assessed using the Sulforhodamine B (SRB) assay on MDA\u2010MB\u2010231 (breast) and A549 (lung) cancer cell lines. The dichloromethane extract showed the strongest cytotoxicity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 24.95 and 28.57\u00a0\u00b5g\/mL, respectively. The essential oil exhibited even greater activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 3.57\u00a0\u00b5g\/mL), with (\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010nerolidol identified as its major component (up to 78.04% in dried leaves). (\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010nerolidol also showed cytotoxicity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 9.04\u00a0\u00b5M). These findings highlight the potential of\n                    <jats:italic>P. mollicomum<\/jats:italic>\n                    , particularly its essential oil, as a natural source of cytotoxic compounds for breast and lung cancer treatment, reinforcing its ethnopharmacological relevance.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71331","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:32:49Z","timestamp":1779355969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and In Vitro Cytotoxic Evaluation of (\n                    <i>E<\/i>\n                    )\u2010Nerolidol From\n                    <i>Piper mollicomum<\/i>\n                    Kunth Essential Oil in Breast and Lung Cancer Cell Lines"],"prefix":"10.1002","volume":"23","author":[{"given":"Let\u00edcia Barbosa","family":"Santos","sequence":"first","affiliation":[{"name":"Departamento De Produtos Farmac\u00eauticos Faculdade De Farm\u00e1cia Universidade Federal de Minas Gerais Av. Ant\u00f4nio Carlos  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-4992","authenticated-orcid":false,"given":"Raquel Speziali Aroeira","family":"Marques dos Santos","sequence":"additional","affiliation":[{"name":"Departamento De Produtos Farmac\u00eauticos Faculdade De Farm\u00e1cia Universidade Federal de Minas Gerais Av. Ant\u00f4nio Carlos  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Couto","family":"Moreira","sequence":"additional","affiliation":[{"name":"Instituto De Ci\u00eancias Biol\u00f3gicas Departamento De Bot\u00e2nica Universidade Federal de Minas Gerais Av. Ant\u00f4nio Carlos  BelocHorizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Pereira","family":"Cosenza","sequence":"additional","affiliation":[{"name":"Departamento De Alimentos Faculdade De Farm\u00e1cia Universidade Federal de Minas Gerais Av. Ant\u00f4nio Carlos  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-5791","authenticated-orcid":false,"given":"Paula Mendon\u00e7a","family":"Leite","sequence":"additional","affiliation":[{"name":"Departamento De Produtos Farmac\u00eauticos Faculdade De Farm\u00e1cia Universidade Federal de Minas Gerais Av. Ant\u00f4nio Carlos  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-9052","authenticated-orcid":false,"given":"Elaine Maria","family":"de Souza\u2010Fagundes","sequence":"additional","affiliation":[{"name":"Departamento De Fisiologia e Biof\u00edsica Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Cristina","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento De Produtos Farmac\u00eauticos Faculdade De Farm\u00e1cia Universidade Federal de Minas Gerais Av. 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Ant\u00f4nio Carlos  Belo Horizonte Minas Gerais Brazil"},{"name":"Cons\u00f3rcio Acad\u00eamico Brasileiro De Sa\u00fade Integrativa  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u2018WHO\u2019 can be found underhttps:\/\/www.who.int\/health\u2010topics\/cancer#tab=tab_1 2022."},{"key":"e_1_2_9_3_1","unstructured":"WHO \u2018Assistive Technology\u2019 can be found underhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/assistive\u2010technology n.d."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201020\u20100007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201017\u20100425"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27259"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112853"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.816"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.129"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102\u201033062004000200019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112123"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.11.055"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11243535"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123064"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11131771"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2020.104116"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5897\/JMPR2013.4425"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11829\u2010019\u201009695\u2010y"},{"key":"e_1_2_9_21_1","first-page":"203","article-title":"Chemodiversity of Essential Oils in Piper L. 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