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The planar and stereochemical structures of\n                    <jats:bold>1<\/jats:bold>\n                    was unambiguously elucidated by comprehensive spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, high\u2010resolution electrospray ionization mass spectrometry (HRESIMS), DP4+ probability analysis, and electronic circular dichroism (ECD) spectroscopy. Compound\n                    <jats:bold>1<\/jats:bold>\n                    represents a structurally unique hybrid molecule, constituting the first naturally occurring conjugate that incorporates both indole 2,5\u2010diketopiperazine alkaloid and terrein structural scaffolds. All isolated compounds were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)\u2010induced RAW 264.7 murine macrophage cells. Among them, compound\n                    <jats:bold>2<\/jats:bold>\n                    exhibited potent in vitro anti\u2010inflammatory activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 22.72\u00a0\u00b1\u00a00.22\u00a0\u00b5M, comparable to the positive control quercetin (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a013.81\u00a0\u00b1\u00a00.35\u00a0\u00b5M).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71351","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:09:41Z","timestamp":1779383381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Spiro\u2010Fused Indole Alkaloid\u2010Terrein Hybrid From Marine\u2010Derived Fungus\n                    <i>Aspergillus chevalieri<\/i>\n                    HK\u201056"],"prefix":"10.1002","volume":"23","author":[{"given":"WanJuan","family":"Xie","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XuHua","family":"Nong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiLin","family":"Kuang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanLing","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XueMing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongMin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University  Haikou Hainan China"},{"name":"Fuyang Institute &amp; 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