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(RDP), a rosa fruit rich in bioactive compounds, has shown potential in alleviating cardiovascular diseases, yet its chemical composition and mechanisms against acute myocardial ischemia (AMI) remain unclear. This study comprehensively characterized 99 compounds in RDP extracts using ultra\u2010high performance liquid chromatography\u2010quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\u2010Q\u2010TOF\u2010MS\/MS), including flavonoids, terpenoids, and phenolic acids. By integrating transcriptomics and network pharmacology, we identified the tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) signaling pathway as a key target in AMI progression. In vivo experiments demonstrated that RDP significantly ameliorated isoproterenol (ISO)\u2010induced myocardial injury by reducing oxidative stress and suppressing the release of inflammatory cytokines (IL\u20106, IL\u20102, IL\u201017). Molecular docking and dynamics simulations further revealed that bioactive components in RDP, such as rutin and hyperoside, effectively bind to TNF\u2010\u03b1 and its receptor TNF receptor 1 (TNFR1), thereby modulating inflammatory responses. These findings provide valuable insights into the multi\u2010target cardioprotective effects of RDP, supporting its application as a promising functional food.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71355","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:58:27Z","timestamp":1779688707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Rosa davurica<\/i>\n                    Pall. as a Functional Food in Ameliorating Acute Myocardial Ischemia: An Integrated Multi\u2010Omics Study on TNF\u2010\u03b1 and Oxidative Stress"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6285-9624","authenticated-orcid":false,"given":"Zeyu","family":"Yi","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin Heilongjiang 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