{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:59:39Z","timestamp":1785085179693,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Polyalthia obliqua<\/jats:italic>\n                    Hook.f. &amp; Thomson is a noteworthy species of the genus\n                    <jats:italic>Polyalthia<\/jats:italic>\n                    with promising medicinal value. The leaf essential oil was analyzed for its chemical composition and biological activities. Gas chromatography\u2010mass spectrometry identified 59 constituents (85.98% of total oil), predominantly oxygenated sesquiterpenoids (73.20%) with spathulenol (28.72%) as the major compound. The oil exhibited antioxidant activity in the 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl assay (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 157.74 \u00b1 3.93\u00a0\u00b5g\/mL); the 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) assay (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 170.00 \u00b1 0.88\u00a0\u00b5g\/mL), and notable inhibition of nitric oxide production (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 54.85\u00a0\u00b5g\/mL). Selective antibacterial effects were observed against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MIC = 64\u00a0\u00b5g\/mL). Molecular docking suggested that khusinol contributes to anti\u2010inflammatory activity via inducible nitric oxide synthase (iNOS) and cyclooxygenase\u20102 (COX\u20102), while both khusinol and 14\u2010oxy\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010muurolene may contribute to antibacterial activity via dihydrofolate reductase (DHFR) and UDP\u2010N\u2010acetylglucosamine enolpyruvyl transferase (MurB). These findings underscore the chemotaxonomic and bioactive potential of\n                    <jats:italic>P. obliqua<\/jats:italic>\n                    essential oil.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71360","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:28:46Z","timestamp":1779690526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Essential\u00a0Oil\u00a0of\n                    <i>Polyalthia obliqua<\/i>\n                    Leaves: GC\u2010MS Composition, Antioxidant, Anti\u2010Inflammatory, Antimicrobial Effects, and Molecular Docking Analysis"],"prefix":"10.1002","volume":"23","author":[{"given":"Trang Huyen Xuan","family":"Hoang","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-8972","authenticated-orcid":false,"given":"Tuan Quoc","family":"Doan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue Vietnam"},{"name":"Graduate School of Environmental Life Natural Science and Technology Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-3665","authenticated-orcid":false,"given":"The\u2010Huan","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuan Hai","family":"Hoang","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dien","family":"Dinh","sequence":"additional","affiliation":[{"name":"Phong Dien Nature Reserve  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-2401","authenticated-orcid":false,"given":"Hoai Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-3022","authenticated-orcid":false,"given":"Linh Thuy Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"\u201cPolyalthia obliquaHook.f. & Thomson | Plants of the World Online | Kew Science \u201d accessed February 28 2025 http:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:74673\u20101."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc\u20102020\u20100097"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.62.843"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.054"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19067621"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070293a"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.886209"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600\u2010014\u20100855\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.13057\/nusbiosci\/n150203"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10236240902765301"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2014.10.028"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.490214"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1009.2012.00303"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1164699"},{"key":"e_1_2_10_16_1","first-page":"2019","article-title":"Monoterpenes Rich Essential Oils From the Leaves of Polyalthia korintii (DUNAL) BENTH. & HOOK. 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P.Murray andJ. M.Leiro \u201cBioactive Sesquiterpene Obtained fromSchinus areiraL. (Anacardiaceae) Essential Oil \u201dProceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry(MDPI 2019) 85 https:\/\/doi.org\/10.3390\/ecsoc\u201023\u201006649.","DOI":"10.3390\/ecsoc-23-06649"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27144631"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12117720"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X1501001033","article-title":"Sesquiterpenes From Essential Oils and Anti\u2010Inflammatory Activity","volume":"10","author":"C\u00e1ssia Da Silveira e S\u00e1 R.","year":"2015","journal-title":"Natural Products Communications"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X211032011","article-title":"Essential Oils of the Leaf and Stem of Polyalthia viridis Craib and Their Biological Activities","volume":"16","author":"Son N. 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