{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:11:10Z","timestamp":1786651870942,"version":"build-2736575974"},"reference-count":83,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present research study explored antidiabetic, antioxidant, and organ\u2010protective properties of\n                    <jats:italic>Cucumis sativus<\/jats:italic>\n                    (cucumber) peel powder (CPP) and ethanol extract of cucumber peel extract (CPE) in alloxan\u2010induced diabetic rats (DR). Chemical profiling of\n                    <jats:italic>C. sativus<\/jats:italic>\n                    peel was done by using GC\u2013MS. The male albino rats (\n                    <jats:italic>n<\/jats:italic>\n                    = 36) were split into six groups, which includes normal control (NC), diabetic control (DC), CPP 5\u00a0mg\/kg oral gavage (CPP\u20105), CPP 10\u00a0mg\/kg (CPP10),\n                    <jats:italic>Cucumis<\/jats:italic>\n                    ethanolic extract 5\u00a0mL\/day (CPE5\n                    <jats:italic>)<\/jats:italic>\n                    , and\n                    <jats:italic>Cucumis<\/jats:italic>\n                    ethanolic extract 10\u00a0mL\/day (CE\u201010). Treatment was applied over a period of 28 days by oral gavage after the induction of alloxan (150\u00a0mg\/kg). A histopathological study was performed on the pancreas, kidney, and liver. In silico study was performed to check the binding affinity of the phytoconstituents with\n                    <jats:italic>\u03b1\u2010amylase<\/jats:italic>\n                    . GC\u2013MS identified bioactive fatty acids, including 9\u2010octadecenoic acid, linoleic acid, and hexadecanoic acid derivatives. Treatment significantly reduced fasting blood glucose and improved insulin levels, lipid profiles, and normalized liver and renal function markers. Histopathological findings showed restoration of pancreatic, hepatic, and renal architecture. Molecular docking revealed strong binding affinity of 9,12,15\u2010octadecatrienoic acid (\u22126.00\u00a0kcal\/mol) toward\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase. Cucumber peel shows promising antihyperglycemic, antihyperlipidemic, and multiorgan protective effects.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71363","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:07:11Z","timestamp":1781244431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Fingerprints by GC\u2013MS, Antidiabetic and Multiorgan Protective Effects of\n                    <i>Cucumis sativus<\/i>\n                    Peel: An Integrated In Vitro, In Vivo, and In Silico Study"],"prefix":"10.1002","volume":"23","author":[{"given":"Hira","family":"Tasleem","sequence":"first","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad","family":"Abbas","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Khurram","family":"Afzal","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Nutrition Bahauddin Zakariya University  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javaria","family":"Saeed","sequence":"additional","affiliation":[{"name":"Southern Punjab Institute of Health Sciences University of Southern Punjab  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-2806","authenticated-orcid":false,"given":"Bipindra","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Madan Bhandari Academy of Health Sciences  Hetauda, Bagmati Province Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waad","family":"Alrohily","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy Taibah University  Medina Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7954-4893","authenticated-orcid":false,"given":"Ali F.","family":"Almutairy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamoud","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy Northern Border University  Rafha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Alfuraih","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy Northern Border University  Rafha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latifah","family":"Al Shammari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy University of Hafr Al Batin  Hafr Al Batin Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mujahid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy University of Hafr Al Batin  Hafr Al Batin Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-4639","authenticated-orcid":false,"given":"Ashfaq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice College of Pharmacy University of Hafr Al Batin  Hafr Al Batin Saudi 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