{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:37Z","timestamp":1783368877122,"version":"3.54.6"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although some Co\u2010bipyridyl systems have been explored in anticancer research, further enhancement in the therapeutic index of mixed\u2010ligand polypyridyl Co\n                    <jats:sup>III<\/jats:sup>\n                    \u2010centered compounds is a prime necessity. In this work, a new octahedral cobalt(III) complex, [Co\n                    <jats:sup>III<\/jats:sup>\n                    (Me\n                    <jats:sub>2<\/jats:sub>\n                    bpy)\n                    <jats:sub>2<\/jats:sub>\n                    (N\n                    <jats:sub>3<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    ]\n                    <jats:sup>+<\/jats:sup>\n                    , featuring 5,5'\u2010dimethyl\u20102,2'\u2010bipyridyl (Me\n                    <jats:sub>2<\/jats:sub>\n                    bpy) and coordinated terminal azide ligands, was synthesized and characterized using single crystal x\u2010ray diffraction and spectroscopic techniques. Density functional theory (DFT) calculations provided insights into the metal\u2013ligand bonding and electronic transitions. Biophysical studies, complemented by molecular docking with calf thymus DNA (ct\u2010DNA) and human serum albumin (HSA) suggested a strong interaction between the Co\n                    <jats:sup>III<\/jats:sup>\n                    complex and ct\u2010DNA. In silico toxicological studies demonstrate a safer toxicity profile of Co\n                    <jats:sup>III<\/jats:sup>\n                    complex than paclitaxel, a clinically approved anticancer drug and comparable to Doxovir, a gold\u2010standard in biologically active Co\n                    <jats:sup>III<\/jats:sup>\n                    \u2010species. In vitro MTT assay showed that the Co\n                    <jats:sup>III<\/jats:sup>\n                    complex is more cytotoxic to glioblastoma multiforme (U87MG; IC\n                    <jats:sub>50<\/jats:sub>\n                    = 29.9 \u00b5M) and human cervical cancer cells (ME\u2010180; IC\n                    <jats:sub>50<\/jats:sub>\n                    = 11 \u00b5M) than its controls in a dose\u2010dependent and apoptotic pathway, with cervical carcinoma cells appearing more susceptible to Co\n                    <jats:sup>III<\/jats:sup>\n                    \u2010mediated effects. The results demonstrate that Co\n                    <jats:sup>III<\/jats:sup>\n                    complex significantly enhances the therapeutic potential of paclitaxel through synergistic cytotoxic and antimigratory effects, underscoring its promise as a chemo adjuvant candidate for combinatorial cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71370","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:48:46Z","timestamp":1780145326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Cancer Cells With Co(III)\u2010Bipyridyl Complex: A Combined In Vitro and In Silico Study on U87MG and ME\u2010180 Cell Lines"],"prefix":"10.1002","volume":"23","author":[{"given":"Shabnam","family":"Sultana","sequence":"first","affiliation":[{"name":"Department of Chemistry Diamond Harbour Women's University  Sarisha West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1256-399X","authenticated-orcid":false,"given":"Tithi","family":"Maity","sequence":"additional","affiliation":[{"name":"Department of Chemistry Natural Science Research Center Prabhat Kumar College (Vidyasagar University)  Contai West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pronab","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Presidency University  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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