{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:35Z","timestamp":1783368875538,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20529"],"award-info":[{"award-number":["U23A20529"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42261144740"],"award-info":[{"award-number":["42261144740"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42361144793"],"award-info":[{"award-number":["42361144793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemical investigation of the mangrove endophytic fungus\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    sp. H6a led to the isolation of six new compounds, including four naphtho\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010pyrone dimers, aurasperones I\u2013L (\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>4<\/jats:bold>\n                    ), a monomeric precursor, rubrofusarin C (\n                    <jats:bold>5<\/jats:bold>\n                    ), and a coumarin, ascoumarin A (\n                    <jats:bold>6<\/jats:bold>\n                    ), along with 12 known analogues (\n                    <jats:bold>7<\/jats:bold>\n                    \u2013\n                    <jats:bold>18<\/jats:bold>\n                    ). Their structures and absolute configurations were established by spectroscopic data, ECD analysis, and the modified Mosher's method. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>17<\/jats:bold>\n                    were evaluated for their cytotoxicity against A549 cancer cells using the CCK\u20108 assay. Compound\n                    <jats:bold>10<\/jats:bold>\n                    showed the most potent activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 11.27 \u00b5M, comparable to cisplatin (DDP) (14.35\u00a0\u00b5M). In DDP\u2010resistant A549\/DDP cells, compound\n                    <jats:bold>10<\/jats:bold>\n                    retained potent activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 12.58\u00a0\u00b5M, markedly lower than that of DDP (40.19\u00a0\u00b5M), and further enhanced the inhibitory effect of DDP when used in combination. These findings expand the chemical diversity of mangrove\u2010derived\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species and offer a candidate for overcoming DDP resistance.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71376","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T18:24:28Z","timestamp":1780251868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Pyranones Isolated From the Mangrove\u2010Associated Endophytic Fungus\n                    <i>Aspergillus<\/i>\n                    sp. H6a"],"prefix":"10.1002","volume":"23","author":[{"given":"Xikang","family":"Zheng","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Mo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Qian","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorao","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3845-6057","authenticated-orcid":false,"given":"Weinan","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-5229","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Natural Drugs Research and Development Dongguan Key Laboratory For Marine Innovative Drugs and Bioproducts School of Pharmacy Guangdong Medical University  Dongguan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.simyco.2020.05.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA01359A"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00041A"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168885"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/np020174p"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.1654"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201300042"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1696793"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00560"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60223a043"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06776"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01262"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.55.685"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19800002474"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules201219767"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18060324"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1043553"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14114433"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19070378"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:20:13Z","timestamp":1783365613000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cbdv.71376"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71376","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71376"}}