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In this communication, we discuss the metabolic and biological differences between bulk tumour cells and CSCs. We further aim to discuss how plant metabolites can reorchestrate CSC signalling pathways, pushing these metabolically precarious cells towards differentiation and cell death. We delineate how plant metabolites curcumin, resveratrol, epigallocatechin gallate (EGCG) and genistein alter signaling in CSCs. 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