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IVLE was extracted by hydrodistillation, and its phytocomposition was evaluated by using GC\u2013MS. IVLE was found to contain 57 components, primarily monoterpenes (67.21%) and sesquiterpenes (30.03%) with \u03b2\u2010linalool, \u03b1\u2010pinene, 1,8\u2010cineole, \u03b2\u2010(E)\u2010ocimene, \u03b1\u2010limonene, \u03b2\u2010(E)\u2010caryophyllene, and \u03b2\u2010elemene as predominant components. Pharmacologically, IVLE exhibited moderate antioxidant activity, as demonstrated by its ability to neutralize DPPH radicals (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0158.16\u00a0\u00b1\u00a01.82\u00a0\u00b5g\/mL). IVLE displayed a substantial NO inhibition with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 47.50\u00a0\u00b1\u00a01.35\u00a0\u00b5g\/mL. Additionally, IVLE also showed significant \u03b1\u2010glucosidase inhibitory activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0166.59\u00a0\u00b1\u00a01.44\u00a0\u00b5g\/mL). Molecular docking studies revealed favorable binding profiles between 57 compositions and the active sites of the iNOS (3E7G), IL\u20101\u03b2 (8C3U), and \u03b1\u2010glucosidase (5NN8) targets, with binding energies ranging from \u22125.2 to \u22127.1\u00a0kcal\/mol, from \u22124.6 to \u22126.9\u00a0kcal\/mol, and from \u22124.8 to \u22127.0\u00a0kcal\/mol, respectively. These results demonstrate that IVLE contains natural phytocompositions with antioxidant, anti\u2010inflammatory, and \u03b1\u2010glucosidase inhibitory capacities. The current work helps expand knowledge of the phytochemical components and bioactivities of IVLE, emphasizing its potential as a natural source with antioxidant, anti\u2010inflammatory, and anti\u2010\u03b1\u2010glucosidase properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71381","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:27:18Z","timestamp":1780291638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Composition and Biological Activities of\n                    <i>Illicium viridiflorum<\/i>\n                    Leaf Essential Oil: Experimental and Molecular Docking Studies"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-9332","authenticated-orcid":false,"given":"Vo Linh","family":"Tu","sequence":"first","affiliation":[{"name":"Faculty of Traditional Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2486-4356","authenticated-orcid":false,"given":"Huynh Thanh","family":"Duy","sequence":"additional","affiliation":[{"name":"Faculty of Traditional Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4777-6243","authenticated-orcid":false,"given":"Duong Thi Ngoc","family":"Lan","sequence":"additional","affiliation":[{"name":"Faculty of Traditional Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-3451","authenticated-orcid":false,"given":"Duong Phan Nguyen","family":"Duc","sequence":"additional","affiliation":[{"name":"Faculty of Traditional Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2324-4038","authenticated-orcid":false,"given":"Hua Thanh Truong","family":"Thinh","sequence":"additional","affiliation":[{"name":"Faculty of Traditional Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-231X","authenticated-orcid":false,"given":"Tran","family":"Van Chen","sequence":"additional","affiliation":[{"name":"Faculty of Traditional Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119829614.ch42"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.01.070"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2020.1746698"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2022.100210"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1586641"},{"key":"e_1_2_9_7_1","first-page":"25577","article-title":"Illicium L. 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