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Koch is a widely distributed species in Central Asia with recognized ethnobotanical importance; however, its seasonal phytochemical variation remains insufficiently characterized. In this study, leaves and flowers collected at different developmental stages were analyzed to evaluate phenolic profiles, mineral composition, and associated biological responses. High\u2010performance liquid chromatography identified apigenin and rutin as the dominant flavonoids in leaves, while flowers showed pronounced but transient increases in flavonoid content during flowering. Inductively coupled plasma\u2013mass spectrometry revealed high levels of potassium, calcium, and magnesium. Ethanolic extracts exhibited low acute toxicity (LD\n                    <jats:sub>50<\/jats:sub>\n                    &gt; 5000\u00a0mg\/kg) and demonstrated measurable biological activity, including attenuation of carbon tetrachloride\u2010induced biochemical alterations and improved tolerance to normobaric hypoxia. Multivariate analysis using principal component analysis revealed clear organ\u2010 and season\u2010dependent differentiation of phytochemical profiles, while partial least squares regression indicated model\u2010indicated associations between chemical composition and physiological response parameters. The results highlight pronounced seasonal and organ\u2010specific variation in\n                    <jats:italic>C. songarica<\/jats:italic>\n                    K. Koch and demonstrate that its biological effects are linked to coordinated phytochemical patterns, supporting its value as a chemically rich plant resource for phytochemical and biodiversity\u2010oriented studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71383","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:28:09Z","timestamp":1781551689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seasonal Phytochemical Profiling and Chemometric Assessment of\n                    <i>Crataegus songarica<\/i>\n                    K. Koch: Implications for Bioactivity and Resource Utilization"],"prefix":"10.1002","volume":"23","author":[{"given":"Zokirova","family":"Mashkhura","sequence":"first","affiliation":[{"name":"Department of Food Technology and Safety Tashkent Institute of Chemical Technology  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-0499","authenticated-orcid":false,"given":"Narges","family":"Samanian","sequence":"additional","affiliation":[{"name":"Department of Food Technology and Safety Tashkent Institute of Chemical Technology  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkin","family":"Botirov","sequence":"additional","affiliation":[{"name":"Institute of the Chemistry of Plant Substances Named After acad. S. Yu. Yunusov Academy of Sciences of the Republic of Uzbekistan  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baratov","family":"Kuzijon","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Screening of Biologically Active Substances Institute of Bioorganic Chemistry Named After acad. O. S. Sadykov Academy of Sciences of the Republic of Uzbekistan  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhmonova","family":"Gulnora","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Screening of Biologically Active Substances Institute of Bioorganic Chemistry Named After acad. O. S. 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