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The structures were elucidated by comprehensive spectroscopic analyses (1D and 2D NMR and HRESIMS) and by comparison with reported data. Compound\n                    <jats:bold>1<\/jats:bold>\n                    exhibited moderate cytotoxicity against K562 human leukemia and SW480 human colon cancer cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 16.72\u00a0\u00b1\u00a00.28 \u00b5M and 17.79\u00a0\u00b1\u00a00.32 \u00b5M, respectively. This work represents the first report of a 5\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ,8\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010epidioxy sterol from the genus\n                    <jats:italic>Mesocentrotus<\/jats:italic>\n                    and adds to the chemical diversity of sea urchin sulfated sterols, providing a basis for further biological evaluation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71393","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:46:01Z","timestamp":1780656361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New Sulfated Cholestane From the Sea Urchin\n                    <i>Mesocentrotus nudus<\/i>\n                    With Cytotoxic Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Huan","family":"Wang","sequence":"first","affiliation":[{"name":"Yantai Institute of Coastal Zone Research Chinese Academy of Sciences  Yantai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Li","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research Chinese Academy of Sciences  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxi","family":"Li","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research Chinese Academy of Sciences  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yantai Institute of Coastal Zone Research Chinese Academy of Sciences  Yantai China"},{"name":"Hebei Chemical and Pharmaceutical College  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