{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:52Z","timestamp":1783368892142,"version":"3.54.6"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The phytochemical profile of several\n                    <jats:italic>Phoenix dactylifera<\/jats:italic>\n                    extracts and evaluation of their antibacterial and anticholinesterase activities were investigated. The extracts were mainly composed of quinic acid, identified as a major constituent in the Ghars variety from Gharda\u00efa extract (GG), and ferulic acid predominating in the ethanolic extract of Deglat nour seeds (DNS). In addition, major flavonoid glycosides such as rutin, isoquercetin, and hesperidin were detected, with the highest levels observed in DNS. DNS and GG were the most antibacterial extracts, while the other fractions were moderate to weak. The strongest effects matched higher phenolic and flavonoid levels (catechin, quinic acid, isoquercetin), suggesting these compounds drive the activity. Enzyme inhibition assays revealed a selective anticholinesterase potential, with the DNS extract exhibiting dual inhibitory activity against acetylcholinesterase (AChE, IC\n                    <jats:sub>50<\/jats:sub>\n                    : 3.17 \u00b1 0.11\u00a0\u00b5g\/mL) and butyrylcholinesterase (BChE, IC\n                    <jats:sub>50<\/jats:sub>\n                    : 52.55 \u00b1 0.72\u00a0\u00b5g\/mL). Notably, the AChE inhibitory activity of DNS was stronger than that of the reference standard galantamine (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 5.01 \u00b1 0.11\u00a0\u00b5g\/mL), while its BChE inhibition was comparable to the standard (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 53.90 \u00b1 0.56\u00a0\u00b5g\/mL). In addition, the Deglat nour spikelet (DNB) extract demonstrated selective BChE inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 43.28 \u00b1 0.83\u00a0\u00b5g\/mL), showing greater potency than galantamine. These findings support the potential use of\n                    <jats:italic>P. dactylifera<\/jats:italic>\n                    as a valuable source of nutraceutical and pharmaceutical compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71404","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:59:37Z","timestamp":1781243977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening of Chemical Profile by Lc\u2010Esi\u2010Ms\/Ms and Assessment of Biological Properties of\n                    <i>Phoenix dactylifera<\/i>\n                    From Algeria"],"prefix":"10.1002","volume":"23","author":[{"given":"Maria","family":"Ferhat","sequence":"first","affiliation":[{"name":"Laboratoire D'obtention De Substances Th\u00e9rapeutiques Chaabet Ersas, Universit\u00e9 Constantine 1\u2010Fr\u00e8res Mentouri  Constantine Algeria"},{"name":"Department of Common Core Faculty of Natural and Life Sciences University of Batna 2 Mostefa Ben Boula\u00efd  Fesdis Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-6769","authenticated-orcid":false,"given":"Ahmed","family":"Kabouche","sequence":"additional","affiliation":[{"name":"Laboratoire D'obtention De Substances Th\u00e9rapeutiques Chaabet Ersas, Universit\u00e9 Constantine 1\u2010Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahia","family":"Kabouche","sequence":"additional","affiliation":[{"name":"Laboratoire D'obtention De Substances Th\u00e9rapeutiques Chaabet Ersas, Universit\u00e9 Constantine 1\u2010Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isil","family":"Gazioglu","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Istanbul University, Bezmialem Vakif  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-6545","authenticated-orcid":false,"given":"G\u00fcla\u00e7t\u0131","family":"Top\u00e7u","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Istanbul University, Bezmialem Vakif  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Application and Research Cente  Diyarbakir T\u00fcrkiye"},{"name":"Faculty of Pharmacy Department of Analytical Chemistry Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-2054","authenticated-orcid":false,"given":"Oguz","family":"Cakir","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Application and Research Cente  Diyarbakir T\u00fcrkiye"},{"name":"Atat\u00fcrk Faculty of Health Sciences Department of Nutrition and Dietetics Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enes","family":"Arica","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Application and Research Cente  Diyarbakir T\u00fcrkiye"},{"name":"Department of Forensic Medicine Dicle University  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1063","article-title":"Flavonoid Content and Antioxidant Profile of Different Date Varieties (Phoenix dactylifera L.) 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