{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:39Z","timestamp":1783368879333,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Herein, we report on the anti\u2010human angiotensin converting enzyme (ACE) properties of 31 hydroethanolic extracts from the edible organs of 30 edible plants consumed in the Northeastern Highlands of Puebla (NHP), Mexico. From the studied extracts, those from\n                    <jats:italic>Solanum nigrescens<\/jats:italic>\n                    ,\n                    <jats:italic>Phaseouls coccineus<\/jats:italic>\n                    ,\n                    <jats:italic>Moninna ciliolata<\/jats:italic>\n                    ,\n                    <jats:italic>Cyclanthera dissecta<\/jats:italic>\n                    , and\n                    <jats:italic>Amanita jacksonii<\/jats:italic>\n                    showed the best inhibitory properties on ACE (IC\n                    <jats:sub>50<\/jats:sub>\n                    , 104.9\u2013211.7\u00a0\u00b5g\/mL). All assayed extracts significantly increased the K\n                    <jats:sub>m<\/jats:sub>\n                    and reduced the V\n                    <jats:sub>max<\/jats:sub>\n                    of ACE, suggesting mixed type inhibition. The HPLC\u2010DAD\u2010MS\/MS profile of the first four species revealed the presence of prenylated anthocyanins and common phenolics as major constituents. The isolation and evaluation of major compounds on ACE, showed that delphinidin\u20103\u2010O\u2010rutinoside, peonidin\u20103\u2010p\u2010hydroxy benzoylsophoroside\u20105\u2010glucoside, chrysin\u20106\u2010C\u2010fucopyranoside, kaempferol, cyanidin\u20103\u2010O\u2010rutinoside\u20105\u2010glucoside, and petunidin\u20103\u2010(cis\u2010p\u2010coumaroyl)\u2010rutinoside\u20105\u2010glucoside were involved in anti\u2010ACE activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    , 86.2\u2013173.1\u00a0\u00b5g\/mL) through competitive inhibition. The oral administration of the studied extracts (100 and 200\u00a0mg\/kg BW) on spontaneous hypertensive rats (SHR) for six weeks significantly decreased systolic blood pressure (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) with substantial improvement from the second to the sixth week post\u2010treatment. Remarkably, only the hydroethanolic extracts from\n                    <jats:italic>P. coccineus<\/jats:italic>\n                    and\n                    <jats:italic>M. ciliolata<\/jats:italic>\n                    (200\u00a0mg\/kg BW) exerted slightly more antihypertensive potency (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) than that of captopril after 6 weeks post\u2010treatment.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71410","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:30:17Z","timestamp":1781847017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antihypertensive Potential of Selected Edible Sources From the Northeastern Highlands of Puebla Mexico and Their Main Phenolic Compounds"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-724X","authenticated-orcid":false,"given":"Yesenia","family":"Pacheco\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"SECIHTI\u2010Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN Unidad Irapuato Km 9.6 Carretera Irapuato\u2010Le\u00f3n Irapuato Guanajuato 36824 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-0355","authenticated-orcid":false,"given":"Edmundo","family":"Lozoya\u2010Gloria","sequence":"additional","affiliation":[{"name":"SECIHTI\u2010Centro de Investigaci\u00f3n y de Estudios Avanzados del IPN Unidad Irapuato Km 9.6 Carretera Irapuato\u2010Le\u00f3n Irapuato Guanajuato 36824 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-2947","authenticated-orcid":false,"given":"Guillermo M.","family":"Horta\u2010Valerdi","sequence":"additional","affiliation":[{"name":"Ingenier\u00eda en Biotecnologia Universidad Polit\u00e9cnica Metropolitana de Puebla Popocat\u00e9petl s\/n, Reserva Territorial Atlixcayotl, Col. Tres Cerritos Puebla Puebla 72480 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4136-5041","authenticated-orcid":false,"given":"Clemente","family":"Mosso\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"SECIHTI\u2010Centro Regional de Investigaci\u00f3n en Salud P\u00fablica (CRISP) 4a. Av. Nte. esquina 19, Norte, Centro Tapachula Chiapas 30700 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2610-2991","authenticated-orcid":false,"given":"Jose Maria","family":"Cunill\u2010Flores","sequence":"additional","affiliation":[{"name":"Abess Center for Ecosystem Science and Policy University of Miami 1365 Memorial Dr #230 Coral Gables Florida 33146 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor","family":"Hern\u00e1ndez\u2010Silva","sequence":"additional","affiliation":[{"name":"Departamento De Ingenier\u00eda Industrial Universidad Del ISTMO Ciudad Universitaria S\/N, Barrio Santa Cruz Tagolaba Tehuantepec Oaxaca 70760 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-2643","authenticated-orcid":false,"given":"Maricruz","family":"Rangel\u2010Galv\u00e1n","sequence":"additional","affiliation":[{"name":"SECIHTI\u2010Direcci\u00f3n de Innovaci\u00f3n y Transferencia de Conocimiento Benem\u00e9rita Universidad Aut\u00f3noma de Puebla 24 Sur y San Claudio, Ciudad Universitaria Puebla Puebla 72570 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-374X","authenticated-orcid":false,"given":"Nemesio","family":"Villa\u2010Ruano","sequence":"additional","affiliation":[{"name":"SECIHTI\u2010Direcci\u00f3n de Innovaci\u00f3n y Transferencia de Conocimiento Benem\u00e9rita Universidad Aut\u00f3noma de Puebla 24 Sur y San Claudio, Ciudad Universitaria Puebla Puebla 72570 Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hipert.2025.02.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.21149\/14779"},{"key":"e_1_2_8_4_1","first-page":"59","article-title":"General Law for Adequate and Sustainable Food: New Policy for Food Security, Food Sovereignty and Nutrition in Mexico\u2032","volume":"12","author":"Ibarra E. 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