{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:53Z","timestamp":1783368893255,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel series of benzothiazole\u2010based furanylthiazolidinone derivatives was designed, synthesized, and biologically evaluated to explore their anticancer potential against triple\u2010negative breast cancer (TNBC). A total of 34 compounds were prepared and screened for in vitro cytotoxic activity against MDA\u2010MB\u2010231 cell lines, along with selectivity assessment in normal HEK\u2010293 cells. Among them, compounds 8j and 8k exhibited the most potent cytotoxic effects, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.57 and 7.48\u00a0\u00b5M, respectively, while demonstrating minimal toxicity toward normal cells. Mechanistic investigations revealed that these compounds induce apoptosis and inhibit tubulin polymerization in a dose\u2010dependent manner, suggesting a microtubule\u2010targeting mode of action. Molecular modeling studies, including binding free energy calculations, further confirmed their strong and stable interactions at the colchicine\u2010binding site of tubulin. In addition, ADME\/T predictions indicated favorable pharmacokinetic profiles, including good oral absorption and acceptable drug\u2010likeness. Overall, this study highlights benzothiazole\u2010based furanylthiazolidinones, particularly compounds 8j and 8k, as promising lead candidates for further development as anticancer agents targeting TNBC.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71423","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:15:43Z","timestamp":1781846143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Biological Evaluation, and In Silico Analysis of Benzothiazolyl\u2013Furano Thiazolidinones as Tubulin Polymerization Inhibitors"],"prefix":"10.1002","volume":"23","author":[{"given":"Bulti","family":"Bakchi","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Hyderabad Telangana 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