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The structures were determined by spectroscopic analysis and comparison with reported data. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    were evaluated for their antichlamydial activities by an experimental model employing L929 cells infected with\n                    <jats:italic>Chlamydia abortus<\/jats:italic>\n                    . Compound\n                    <jats:bold>3<\/jats:bold>\n                    , at a concentration of 100 \u00b5M, exhibited activity comparable to that of the positive control tetracycline at a concentration of 20 \u00b5g\/mL, while showing no cytotoxicity. Preliminary structure\u2013activity relationships for these eremophilenolides are reported.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71429","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:05:51Z","timestamp":1781708751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eremophilane Sesquiterpenes With Antichlamydial Activity Isolated From\n                    <i>Ligularia macrophylla<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Na","family":"Gao","sequence":"first","affiliation":[{"name":"Research Institute School of Chemistry and Chemical Engineering Lanzhou Jiaotong University  Lanzhou People's Republic of China"},{"name":"School of Public Health Gansu University of Chinese Medicine  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Li","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute School of Chemistry and Chemical Engineering Lanzhou Jiaotong University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Tao","family":"Zha","sequence":"additional","affiliation":[{"name":"Research Institute School of Chemistry and Chemical Engineering Lanzhou Jiaotong University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Institute School of Chemistry and Chemical Engineering Lanzhou Jiaotong University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6494-3486","authenticated-orcid":false,"given":"Yi\u2010Lin","family":"He","sequence":"additional","affiliation":[{"name":"Research Institute School of Chemistry and Chemical Engineering Lanzhou Jiaotong University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-6554","authenticated-orcid":false,"given":"Tong","family":"Shen","sequence":"additional","affiliation":[{"name":"Research Institute School of Chemistry and Chemical Engineering Lanzhou Jiaotong University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.05.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2478\/jvetres-2023-0067"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2025.06.014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.70069"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60091515"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16030415"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0294"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1578678"},{"issue":"3","key":"e_1_2_9_10_1","first-page":"656","article-title":"In Vitro Antibacterial Activity of Selected Palestinian Medicinal Plants Against Chlamydia Trachomatis","volume":"12","author":"Hamarsheh O.","year":"2021","journal-title":"Microbiological Research"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-011-1051-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB10.1713"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.12.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29071519"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.073"},{"issue":"9","key":"e_1_2_9_16_1","article-title":"Chemical Studies of Cremanthodium (Asteraceae) Species; Sesquiterpenoids and Related Compounds","volume":"14","author":"Tori M.","year":"2019","journal-title":"Natural Products Communications"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.03.002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-020-02970-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","unstructured":"Y. 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