{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:09Z","timestamp":1783368849039,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277152"],"award-info":[{"award-number":["22277152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ferroptosis is an iron\u2010dependent form of regulated cell death that plays a critical role in the pathogenesis of multiple human diseases, making it an attractive target for therapeutic strategy. In this study, the FerrBERT model was employed to screen a small\u2010molecule library, leading to the identification of 3\u2010amino\u20109\u2010ethylcarbazole as a potent inhibitor of RSL3\u2010induced ferroptosis in HT22 mouse hippocampal neuronal cells (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a065.2\u00a0nM). Using this scaffold as a starting point, 50 derivatives were designed, synthesized, and systematically evaluated for their structure\u2013activity relationships (SARs). Among them, compound\n                    <jats:bold>C4<\/jats:bold>\n                    exhibited a remarkable enhancement in inhibitory potency, showing an approximately 8.4\u2010fold improvement over the lead compound while maintaining low cytotoxicity (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a07.77\u00a0nM; CC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a05.97 \u00b5M; SI\u00a0=\u00a0768). Mechanistic studies further revealed that\n                    <jats:bold>C4<\/jats:bold>\n                    selectively suppresses ferroptosis through an antioxidant\u2010mediated pathway. Collectively, these findings identified\n                    <jats:bold>C4<\/jats:bold>\n                    as a highly potent ferroptosis inhibitor with significant potential for the development of therapeutics targeting ferroptosis\u2010related neurological disorders.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71430","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:33:01Z","timestamp":1781515981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery and Optimization of Novel Carbazole\u2010Based Ferroptosis Inhibitors"],"prefix":"10.1002","volume":"23","author":[{"given":"Chuantong","family":"Zhou","sequence":"first","affiliation":[{"name":"Guangdong Pharmaceutical University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Yao","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifeng","family":"Teng","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University  Guangzhou People's Republic of China"},{"name":"School of Chinese Medicine Guangdong Pharmaceutical University  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Gu","sequence":"additional","affiliation":[{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou People's Republic of 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