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The UHPLC\u2010DAD\u2010MS analysis revealed caffeoylquinic acid isomers, flavonols (quercetin and kaempferol types), and flavones (luteolin derivatives) in both species, while cynarine\u00a0was detected in\n                    <jats:italic>U. dalechampii<\/jats:italic>\n                    .\u00a0 Some compounds were specific, such as caftaric acid, which was detected only in\n                    <jats:italic>U. dalechampii<\/jats:italic>\n                    \u00a0leaf extract. Both species exhibited notable antioxidant capacities, with\n                    <jats:italic>U. dalechampii\u00a0<\/jats:italic>\n                    showing stronger radical\u2010scavenging activity (DPPH: EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0 = 0.95\u00a0mg\/mL; ABTS: EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0 = 0.72\u00a0mg\/mL), whereas\n                    <jats:italic>A. integrifolia<\/jats:italic>\n                    \u00a0displayed higher reducing power (FRAP: EC\n                    <jats:sub>50<\/jats:sub>\n                    = 5.40\u00a0mg\/mL) and copper\u2010chelating activity (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0 = 1.72\u00a0mg\/mL).\n                    <jats:italic>A. integrifolia<\/jats:italic>\n                    \u00a0showed marked inhibition of tyrosinase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0 = 0.54\u00a0mg\/mL), \u03b1\u2010glucosidase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0 = 1.9\u00a0mg\/mL), and lipase (IC\n                    <jats:sub>50\u00a0<\/jats:sub>\n                    = 9.7\u00a0mg\/mL). Both leaf extracts from studied species inhibited AChE, while only\n                    <jats:italic>A. integrifolia<\/jats:italic>\n                    \u00a0inhibited BChE (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0 = 8.63\u00a0mg\/mL). No cytotoxicity was detected at 100\u00a0\u00b5g\/mL in human hepatocarcinoma (HepG2), neuroblastoma (SH\u2010SY5Y), embryonic kidney (HEK\u2010293), and murine melanoma (B16) cells. These results highlight these two plants as a promising source of multifunctional bioactive compounds and demonstrate that unexploited wild plants could offer new prospects for pharmaceutical and nutraceutical applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71434","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:38:37Z","timestamp":1781883517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediterranean Asteraceae as Natural Sources of Antioxidants and Enzyme Inhibitors: A Case Study on\n                    <i>Urospermum dalechampii<\/i>\n                    and\n                    <i>Andryala integrifolia<\/i>\n                    From Tunisia"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8820-6682","authenticated-orcid":false,"given":"Nourhen","family":"Hammami","sequence":"first","affiliation":[{"name":"Laboratory of Plant Productivity and Environmental Constraint LR18ES04 Department of Biology Faculty of Sciences of Tunis University Tunis El Manar  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-710X","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias do Mar do Algarve (CCMAR\/CIMAR LA) Campus De Gambelas Universidade Do Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-8353","authenticated-orcid":false,"given":"Eliana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias do Mar do Algarve (CCMAR\/CIMAR 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