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To identify new pneumocandin analogues, a chemical reinvestigation was carried out on\n                    <jats:italic>G. lozoyensis<\/jats:italic>\n                    . This endeavor resulted in the isolation of pneumocandin B\n                    <jats:sub>0<\/jats:sub>\n                    and two previously undescribed pneumocandin derivatives, designated as pneumocandins B\n                    <jats:sub>7<\/jats:sub>\n                    and B\n                    <jats:sub>8<\/jats:sub>\n                    . Their structures were elucidated using HRESIMS and NMR spectroscopic analyses. Pneumocandins B\n                    <jats:sub>7<\/jats:sub>\n                    and B\n                    <jats:sub>8<\/jats:sub>\n                    represent the first reported pneumocandin analogues with a hydroxylated 10,12\u2010dimethylmyristate (DMM) moiety. Antifungal activity assays revealed that pneumocandins B\n                    <jats:sub>7<\/jats:sub>\n                    and B\n                    <jats:sub>8<\/jats:sub>\n                    exhibited reduced antifungal efficacy across all eight tested\n                    <jats:italic>Candida<\/jats:italic>\n                    strains in comparison to pneumocandin B\n                    <jats:sub>0<\/jats:sub>\n                    . These findings suggest that the introduction of a hydroxyl group in the DMM moiety has a negative effect on the antifungal activity. These results enrich the structural diversity of the pneumocandin family and provide new insights into the structure\u2010activity relationship of pneumocandins.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71436","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:35:21Z","timestamp":1781883321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Undescribed Pneumocandin Analogues From\n                    <i>Glarea lozoyensis<\/i>\n                    and Evaluation of Their Antifungal Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Qianfei","family":"Huang","sequence":"first","affiliation":[{"name":"School of Pharmacy Fujian University of Traditional Chinese Medicine  Fuzhou China"},{"name":"School of Pharmacy Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy Fujian University of Traditional Chinese Medicine  Fuzhou China"},{"name":"School of Pharmacy Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Guoyang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Surgery the First Affiliated Hospital of the Naval Medical University (Changhai Hospital) School of Traditional Chinese Medicine Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy Fujian University of Traditional Chinese Medicine  Fuzhou China"},{"name":"School of Pharmacy Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2050224"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9050227"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-11022-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040192"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3NP70070D"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo062008i"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.174"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.163"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.168"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.1953"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.1875"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.1867"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.1853"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(98)00804-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jim.7000115"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0261940"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-339"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00604"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.1096-1099.2006"}],"container-title":["Chemistry &amp; 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