{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:08Z","timestamp":1788858548453,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dysphania ambrosioides<\/jats:italic>\n                    L. (Amaranthaceae) is a medicinal plant widely used in traditional Moroccan medicine for the management of diabetes\u2010related disorders. This study investigated the antidiabetic, antioxidant, and antibacterial activities of its hydroethanolic extract. Antidiabetic potential was evaluated through pancreatic \u03b1\u2010amylase inhibition (in vitro and in vivo) and intestinal glucose absorption (in situ). Antioxidant and antibacterial activities were assessed using standard chemical assays and selected bacterial strains. The extract showed significant inhibition of pancreatic \u03b1\u2010amylase in vitro (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.22 \u00b1 0.18\u00a0mg\/mL). In vivo, it markedly reduced starch\u2010induced hyperglycemia in both normal and alloxan\u2010induced diabetic rats (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and decreased intestinal glucose absorption in situ (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). It also exhibited broad\u2010spectrum antibacterial activity against\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , with MIC values ranging from 0.07 to 0.625\u00a0mg\/mL and MBC values from 0.312 to 1.25\u00a0mg\/mL. Moderate antioxidant activity was observed using the ABTS assay (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 293.98 \u00b1 3.11\u00a0mg\/mL), along with a high total antioxidant capacity. These results demonstrate that\n                    <jats:italic>Dysphania ambrosioides<\/jats:italic>\n                    exerts antidiabetic effects through inhibition of carbohydrate digestion and glucose absorption, alongside antioxidant and antibacterial activities. This study provides scientific evidence supporting its traditional use and highlights its potential as a natural source of bioactive compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71437","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:11:11Z","timestamp":1786813871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro and In Vivo Evaluation of the Antidiabetic, Antioxidant, and Antibacterial Activities of the Hydroethanolic Extract of\n                    <i>Dysphania ambrosioides<\/i>\n                    L."],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2696-1734","authenticated-orcid":false,"given":"Fahd","family":"Kandsi","sequence":"first","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Zahra","family":"Lafdil","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-0122","authenticated-orcid":false,"given":"Saliha","family":"Bouknana","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-5914","authenticated-orcid":false,"given":"Naoufal","family":"El Hachlafi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Biotechnology and Bioactive Molecules, Faculty of Sciences and Technologies Sidi Mohamed Ben Abdellah University  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-1842","authenticated-orcid":false,"given":"Mohamed","family":"Jeddi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Biotechnology and Bioactive Molecules, Faculty of Sciences and Technologies Sidi Mohamed Ben Abdellah University  Fez Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Conte","sequence":"additional","affiliation":[{"name":"Research Institute on Terrestrial Ecosystems (IRET)\u2010CNR  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-1290","authenticated-orcid":false,"given":"Mohamed","family":"Bnouham","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-9299","authenticated-orcid":false,"given":"Kaoutar","family":"Fikri\u2010Benbrahim","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Gseyra","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences Mohammed First University  Oujda Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010023\u201002658\u20104"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11040482"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094\u2010021\u201000306\u20103"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4236\/abc.2021.115015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2007.111.115"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2018.11.059"},{"issue":"5","key":"e_1_2_8_8_1","first-page":"34","article-title":"Anti\u2010Inflammatory Effect of Mastruz (Chenopodium ambrosioides) Extract in Respiratory Distress Syndrome","volume":"5","author":"Carvalho e Silva M. 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