{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:35:48Z","timestamp":1789104948738,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, a new series of chalcone (\n                    <jats:bold>2a<\/jats:bold>\n                    \u2013\n                    <jats:bold>2k<\/jats:bold>\n                    ) and pyrazoline compounds (\n                    <jats:bold>3a<\/jats:bold>\n                    \u2013\n                    <jats:bold>3k<\/jats:bold>\n                    ) activity were synthesized via Claisen\u2013Schmidt condensation followed by cyclization reactions. The anticancer activities of compounds (\n                    <jats:bold>2a<\/jats:bold>\n                    \u2013\n                    <jats:bold>2k<\/jats:bold>\n                    and\n                    <jats:bold>3a<\/jats:bold>\n                    \u2013\n                    <jats:bold>3k<\/jats:bold>\n                    ) were evaluated systematically against three human cancer cell lines: human colon cancer (HT29), lung (A549), and breast (MCF\u20107) carcinoma cells. The compounds\n                    <jats:bold>2f<\/jats:bold>\n                    ,\n                    <jats:bold>2j<\/jats:bold>\n                    , and\n                    <jats:bold>2k<\/jats:bold>\n                    showed notable anticancer properties against the HT29 cancer cell lines with a favorable selectivity profile. Compounds\n                    <jats:bold>2f<\/jats:bold>\n                    ,\n                    <jats:bold>2j<\/jats:bold>\n                    , and\n                    <jats:bold>2k<\/jats:bold>\n                    exhibited vascular endothelial growth factor (VEGF) receptor\u20102 (VEGFR\u20102) enzyme inhibition with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.118 \u00b1 0.019, 0.071 \u00b1 0.009, and 0.235 \u00b1 0.069\u00a0\u00b5M, respectively. Molecular docking and molecular dynamics studies of\n                    <jats:bold>2f<\/jats:bold>\n                    ,\n                    <jats:bold>2j<\/jats:bold>\n                    , and\n                    <jats:bold>2k<\/jats:bold>\n                    were performed using the crystal structure of the VEGFR\u20102 enzyme (PDB ID: 4ASD). Furthermore, the pharmacokinetics and druglikeness of the compounds were appraised using the SwissADME program.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71441","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:39:33Z","timestamp":1782293973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis, Anticancer Activity Evaluation, and Molecular Docking Studies of Some New Chalcone and Pyrazoline Derivatives"],"prefix":"10.1002","volume":"23","author":[{"given":"\u015eevval Ruken","family":"Baltac\u0131","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Biruni University  \u0130stanbul T\u00fcrkiye"},{"name":"Institute of Health Sciences Marmara University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-436X","authenticated-orcid":false,"given":"Derya","family":"Osmaniye","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Anadolu University  Eski\u015fehir T\u00fcrkiye"},{"name":"Central Research Laboratory (MERLAB) Faculty of Pharmacy Anadolu University  Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"\u00d6zkay","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Anadolu University  Eski\u015fehir T\u00fcrkiye"},{"name":"Central Research Laboratory (MERLAB) Faculty of Pharmacy Anadolu University  Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-0923","authenticated-orcid":false,"given":"Zafer As\u0131m","family":"Kaplanc\u0131kl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Anadolu University  Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bedia","family":"Ko\u00e7yi\u011fit\u2010Kaymak\u00e7\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Biruni University  \u0130stanbul T\u00fcrkiye"},{"name":"Biruni University Research Center (B@MER) Biruni University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4569-008X","authenticated-orcid":false,"given":"Fatih","family":"Tok","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Marmara University  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21788"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154430"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(24)00600\u20104"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001738\u20106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010023\u201008809\u20103"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111694"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060894"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26237177"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27207062"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c01035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112215"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.01.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.09.026"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.592654"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26237134"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020299"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612724"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113439"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155507"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfad036"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.667403"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112666"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117585"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1488853"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30234526"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2278022"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401991"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.109075"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.70056"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100762r"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139732"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140298"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147929"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.05.004"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.70061"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.10.029"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105487"},{"issue":"4","key":"e_1_2_9_39_1","first-page":"205","article-title":"Spectral Properties of Chalcones II","volume":"37","author":"Aks\u00f6z B. E.","year":"2012","journal-title":"Fabad Journal of Pharmaceutical Sciences"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30143032"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24234236"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.2256"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MD00910C"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136903"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104665"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138978"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2024-0005"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.17344\/acsi.2021.7119"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2017.1395878"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051054"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112979"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2020.1776319"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180814666161207163450"},{"key":"e_1_2_9_54_1","unstructured":"ABP Biosciences \u201cApoptotic Necrotic and Healthy Cells Detection Kit \u201dABP Biosciences(2025)."},{"key":"e_1_2_9_55_1","unstructured":"BPS Bioscience \u201cVEGFR\u20102\/KDR Kinase Assay Kit \u201dBPS Bioscience."},{"key":"e_1_2_9_56_1","unstructured":"RCSB Protein Data Bank \u201cCrystal Structure of VEGFR\u20102 (Juxtamembrane and Kinase Domains) in Complex With Sorafenib (BAY 43\u20109006) \u201dRCSB Protein Data Bank(2012) PDB ID 4ASD."},{"key":"e_1_2_9_57_1","unstructured":"L. L. C.Schr\u00f6dinger \u201cMaestro \u201d (2020) version 10.6."},{"key":"e_1_2_9_58_1","unstructured":"L. L. C.Schr\u00f6dinger \u201cLigPrep \u201d (2020) version 3.8."},{"key":"e_1_2_9_59_1","unstructured":"L. L. C.Schr\u00f6dinger \u201cGlide \u201d (2020) version 7.1."},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2018.1403419"},{"key":"e_1_2_9_61_1","unstructured":"LLC Schr\u00f6dinger Prime (M.D.I. Tools) Schr\u00f6dinger Release 2018\u20103(2018)."},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.04.077"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100078a035"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.31.1695"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.467468"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.142036"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139012"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:19:18Z","timestamp":1783365558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cbdv.71441"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71441","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71441"}}