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In this study, 16 compounds, including two new terpenoids (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    ) and 14 known monoterpenoids (\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4\u201316<\/jats:bold>\n                    ), were isolated from\n                    <jats:italic>D. kaki<\/jats:italic>\n                    leaves using an MS\/MS molecular networking approach. Their structures were elucidated via NMR, quantum chemical NMR, and ECD calculations. Neuroprotective screening in OGD\/R\u2010injured HT22 cells showed that compounds\n                    <jats:bold>7<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    exhibited significant activity. They reduced apoptosis and intracellular ROS accumulation. Mechanistic studies, including network pharmacology, molecular docking, molecular dynamics, and Western blotting, confirmed that\n                    <jats:bold>7<\/jats:bold>\n                    and\n                    <jats:bold>14<\/jats:bold>\n                    protect neurons by inhibiting the JAK2\/STAT3 signaling pathway. This work reveals terpenoids from\n                    <jats:italic>D. kaki<\/jats:italic>\n                    leaves as potential anti\u2010ischemic agents, clarifies the active material basis of\n                    <jats:italic>NaoXinQing<\/jats:italic>\n                    and persimmon leaf tea, and supports further development of this medicinal resource.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71443","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:15:18Z","timestamp":1783368918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Terpenoids From Leaves of\n                    <i>Diospyros kaki<\/i>\n                    and Their Neuroprotective Effects"],"prefix":"10.1002","volume":"23","author":[{"given":"Yirou","family":"Xue","sequence":"first","affiliation":[{"name":"Key Laboratory of Computational Chemistry\u2010Based Natural Antitumor Drug Research &amp; Development  Liaoning China"},{"name":"Engineering Research Center of Natural Medicine Active Molecule Research &amp; Development  Liaoning China"},{"name":"Key Laboratory of Natural Bioactive Compounds Discovery &amp; Modification  Shenyang China"},{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Chemistry\u2010Based Natural Antitumor Drug Research &amp; Development  Liaoning China"},{"name":"Engineering Research Center of Natural Medicine Active Molecule Research &amp; Development  Liaoning China"},{"name":"Key Laboratory of Natural Bioactive Compounds Discovery &amp; Modification  Shenyang China"},{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Liu","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation Shenyang Pharmaceutical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Chemistry\u2010Based Natural Antitumor Drug Research &amp; 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