{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:22Z","timestamp":1783368862410,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006418","name":"Yarmouk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study reports, for the first time, the phytochemical characterization and biological evaluation of the essential oils (EOs) and solvent extracts of\n                    <jats:italic>Alkanna strigosa<\/jats:italic>\n                    collected from Jordan. Gas chromatography\u2013mass spectrometry (GC\u2013MS) analysis of the fresh and air\u2010dried plant's EOs led to the identification of 38 and 32 constituents, representing 98.13% and 97.45% of the total compositions, respectively. Oxygenated sesquiterpenes were the predominant class in both oils (34.25% and 60.66%). The EOs exhibited strong antioxidant activity, with low IC\n                    <jats:sub>50<\/jats:sub>\n                    values in DPPH (5.79 and 10.0\u00a0\u00b5g\/mL) and ABTS (1.18 and 1.15\u00a0\u00b5g\/mL) assays for FEO and DEO, respectively. Soxhlet extraction using solvents of increasing polarity afforded ethyl acetate (ASE), acetone (ASA), and methanol (ASM) extracts. LC\u2013MS\/MS profiling revealed a high abundance of phenolic compounds and flavone glycosides, particularly in the ASM extract, which showed notable antioxidant activity. All extracts exhibited weak acetylcholinesterase inhibitory effects and lacked significant antibacterial activity against selected Gram\u2010positive and Gram\u2010negative bacteria. Furthermore, no relevant cytotoxic effects were observed against cancerous or normal cell lines. These findings highlight\n                    <jats:italic>A. strigosa<\/jats:italic>\n                    as a promising natural source of antioxidant and neuroprotective compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71444","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:31:41Z","timestamp":1781847101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Composition and Biological Activities of\n                    <i>Alkanna strigosa<\/i>\n                    Essential Oil: GC\u2013MS Analysis, LC\u2013MS\/MS Profiling of Extracts, Antioxidant, and Anticholinesterase Evaluation"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-8249","authenticated-orcid":false,"given":"Mahmoud A.","family":"Al\u2010Qudah","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen A.","family":"Shawaheen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala I.","family":"Al\u2010Jaber","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Al\u2010Balqa Applied University  Al\u2010Salt Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael A.","family":"Al\u2010Zereini","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Faculty of Science Mutah University  Al\u2010Karak Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Al\u2010Dalahmeh","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences Faculty of Pharmacy Isra University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan T.","family":"Abu\u2010Orabi","sequence":"additional","affiliation":[{"name":"Department of Medical Analysis Faculty of Science Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-3622","authenticated-orcid":false,"given":"Abdulrahman G.","family":"Alhamzani","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u201000114\u2010z"},{"key":"e_1_2_9_3_1","first-page":"45","article-title":"Flora of Jordan: Diversity, Distribution and Conservation Status","volume":"9","author":"Al\u2010Eisawi D. 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