{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:41Z","timestamp":1785330341103,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The isoquinoline alkaloids from\n                    <jats:italic>Corydalis impatiens<\/jats:italic>\n                    (Pall.) Fisch, a traditional Tibetan medicine used for treating liver diseases, are considered to be a major bioactive constituent potentially contributing to its hepatoprotective activity. This study aimed to systematically characterize the isoquinoline alkaloids in\n                    <jats:italic>C. impatiens<\/jats:italic>\n                    and expand their chemical inventory, thereby providing a basis for understanding their potential bioactivity and further application. UPLC\u2010QTOF\u2010MS\/MS combined with a feature\u2010based molecular networking (FBMN) approach was employed to comprehensively profile the isoquinoline alkaloids. In this way, the cleavage patterns and diagnostic ions of different isoquinoline alkaloid types were systematically summarized, and a total of 74 isoquinoline alkaloids were identified, including 20 tetrahydroprotoberberines, 13 phthalide isoquinolines, 19 protoberberines, 4 protopines, 17 benzylisoquinolines, and 1 benzophenanthridine. Among these, eight compounds were tentatively identified as putatively new alkaloids belonging to the phthalide isoquinoline\u2010type and benzylisoquinoline\u2010type alkaloids. In addition, distributional differences among\n                    <jats:italic>C. impatiens<\/jats:italic>\n                    samples were investigated. This study expanded the current understanding of isoquinoline alkaloids in\n                    <jats:italic>C. impatiens<\/jats:italic>\n                    . Moreover, the FBMN approach proved to be a rapid and effective strategy for characterizing complex chemical compositions and discovering new compounds in crude drugs.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71448","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:19:31Z","timestamp":1783369171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systematic Characterization of Isoquinoline Alkaloids Constituents in\n                    <i>Corydalis impatiens<\/i>\n                    (Pall.) Fisch Based on UPLC\u2010QTOF\u2010MS\/MS Combined With Feature\u2010Based Molecular Networking"],"prefix":"10.1002","volume":"23","author":[{"given":"En","family":"Yuan","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Sustainable Utilization of Traditional Chinese Medicine Resources Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-1935","authenticated-orcid":false,"given":"Yuzhuo","family":"Dong","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Sustainable Utilization of Traditional Chinese Medicine Resources Jiangxi University of Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhi","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jiangxi University of Chinese Medicine  Nanchang 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