{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:35Z","timestamp":1785330335869,"version":"3.55.0"},"reference-count":102,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the bioactivity potential of Chrysanthemum macrocarpum aerial part extracts used in traditional Algerian medicine, providing the first LC\u2013ESI\u2013MS\/MS characterization of their phenolic composition alongside evaluation of antioxidant, enzyme inhibitory, photoprotective, cytotoxic, and antibacterial activities. LC\u2013ESI\u2013MS\/MS analysis revealed distinct phenolic profiles, identifying 9 compounds in ethyl acetate (EAFCM) and 15 in n\u2010butanol (BFCM), with EAFCM particularly rich in gentisic (10.428\u00a0mg\/g), caffeic (3.962\u00a0mg\/g), chlorogenic acids (2.731\u00a0mg\/g), cynaroside (5.927\u00a0mg\/g), and astragalin (3.023\u00a0mg\/g). EAFCM exhibited higher total phenolic (135.25\u00a0\u00b1\u00a05.09\u00a0\u00b5g PEs\/mg) and flavonoid contents (135.2\u00a0\u00b1\u00a01.23\u00a0\u00b5g QE\/mg) than BFCM. Accordingly, EAFCM showed stronger antioxidant activity (DPPH: IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a04.51\u00a0\u00b1\u00a00.22\u00a0\u00b5g\/mL; ABTS: IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a05.11\u00a0\u00b1\u00a00.60\u00a0\u00b5g\/mL; CUPRAC: A\n                    <jats:sub>0<\/jats:sub>\n                    .\n                    <jats:sub>5<\/jats:sub>\n                    \u00a0=\u00a013.51\u00a0\u00b1\u00a00.26\u00a0\u00b5g\/mL; phenanthroline: A\n                    <jats:sub>0<\/jats:sub>\n                    .\n                    <jats:sub>5<\/jats:sub>\n                    \u00a0=\u00a04.31\u00a0\u00b1\u00a00.47\u00a0\u00b5g\/mL; FRAP: A\n                    <jats:sub>0<\/jats:sub>\n                    .\n                    <jats:sub>5<\/jats:sub>\n                    \u00a0=\u00a013.30\u00a0\u00b1\u00a00.30\u00a0\u00b5g\/mL). Enzyme inhibition assays showed weak activity against \u03b1\u2010amylase, tyrosinase, and cholinesterase. Both extracts exhibited strong photoprotective effects (SPF\u00a0&gt;\u00a040) and low cytotoxicity, with EAFCM selectively reducing T98G cell viability. EAFCM showed antibacterial activity against Gram\u2010positive bacteria, while Gram\u2010negative inhibition was weak. These results indicate that\n                    <jats:italic>C. macrocarpum<\/jats:italic>\n                    , aerial part extracts have potential as antioxidant, photoprotective, and antibacterial agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71454","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:12:43Z","timestamp":1783368763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LC\u2013ESI\u2013MS\/MS Characterization and Biological Activities of Ethyl Acetate and\n                    <i>n<\/i>\n                    \u2010Butanol Fractions of\n                    <i>Chrysanthemum macrocarpum<\/i>\n                    From Algeria"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5821-0977","authenticated-orcid":false,"given":"Nesrine","family":"Bradai","sequence":"first","affiliation":[{"name":"Laboratoire D'obtention De 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T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa","family":"Abdullah Yilmaz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Analytical Chemistry Dicle University  Diyarbakir T\u00fcrkiye"},{"name":"Dicle University Science and Technology Application and Research Center  Diyarbakir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6738-7527","authenticated-orcid":false,"given":"Alevcan","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Botany Dicle University  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgi Irtegun","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Application and Research Center  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