{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:33Z","timestamp":1783368873366,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110100"],"award-info":[{"award-number":["2022A1515110100"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    By phytochemically profiling the methanolic extract of\n                    <jats:italic>Actinidia polygama<\/jats:italic>\n                    gall fruits, we isolated six iridoid glycosides, comprising five new derivatives named actinidiosides A\u2013E (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>6<\/jats:bold>\n                    ), and one known analogue, actinidin A (\n                    <jats:bold>2<\/jats:bold>\n                    ). Their planar structures were established by comprehensive 1D\/2D NMR and high\u2010resolution mass spectrometry analyses, while stereochemical assignments were achieved through electronic circular dichroism spectroscopy, and GIAO\/DP4+ NMR chemical shift calculations. The isolated compounds were screened for cytotoxicity and inhibition of NO production in RAW264.7 macrophage cells. An MTT assay demonstrated no cytotoxicity at concentrations up to 100\u00a0\u00b5M. However, none of the isolates inhibited lipopolysaccharide\u2010induced nitric oxide production under the evaluated conditions. This work expands the secondary metabolite profile of\n                    <jats:italic>A. polygama<\/jats:italic>\n                    and provides fully characterized iridoid scaffolds for future chemical and pharmacological investigations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71457","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:54:22Z","timestamp":1782294862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Actinidiosides A\u2013E: Five New Iridoid Glycosides From the Gall Fruits of\n                    <i>Actinidia polygama<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-2012","authenticated-orcid":false,"given":"Xiangdong","family":"Su","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science (Shenzhen) Sun Yat\u2010sen University  Shenzhen People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1715-4455","authenticated-orcid":false,"given":"Nguyen Viet","family":"Phong","sequence":"additional","affiliation":[{"name":"Department of Biology Education Teachers College and Institute for Phylogenomics and Evolution Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myungsook","family":"Heo","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-1019","authenticated-orcid":false,"given":"Sung Don","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Applied Plant Sciences, Graduate School Sangji University  Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-1374","authenticated-orcid":false,"given":"Seo Young","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biology Education Teachers College and Institute for Phylogenomics and Evolution Kyungpook National University  Daegu Republic of Korea"},{"name":"Department of Advanced Bioconvergence BK21 FOUR KNU Center for Innovative One\u2010Health Leaders Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117222"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/fft2.70041"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28237820"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.15588"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01236"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000925"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201500518"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.139135"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14925"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1278592"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110654"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02994759"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.10.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1239"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.23.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106466"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100028\u20101097333"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.111"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2025.102757"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.17466"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005806607349"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.12651\/JSR.2025.14.3.321"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1978.433"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(00)75373\u20101"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.37.1888"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)94767\u20108"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(92)83634\u2010B"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.03.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107230"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja105035r"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo900408d"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.3c00566"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.5491"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2025.105060"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102440\u20105166"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c12435"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262211202"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.4007"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202201098"}],"container-title":["Chemistry 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