{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:43Z","timestamp":1785330343166,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Over 25% of people worldwide have liver illnesses, which kill nearly 2 million. This study assessed the hepatoprotective potential of\n                    <jats:italic>Baccaurea motleyana<\/jats:italic>\n                    fruit acetone extract (BMF\u2010AE) against CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced liver injury. GC\u2013MS phytochemical profiling identified nine metabolites, with linoleic acid ethyl ester, quercetin, and gallic acid as predominant bioactives known for hepatoprotective activity. The antioxidant activity of BMF\u2010AE was significant in DPPH and ABTS assays, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 112.55 and 127\u00a0\u00b5g\/mL, respectively. In vivo hepatoprotective efficacy was assessed in five groups (\n                    <jats:italic>n<\/jats:italic>\n                    = 5) that received oral BMF\u2010AE (200 or 400\u00a0mg\/kg) for 14 days. Positive control was 100\u00a0mg\/kg silymarin. The CCl4\u2010induced increase in serum ALT, AST, ALP, and bilirubin was dramatically reduced, while BMF\u2010AE restored albumin levels (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Treatment reduced hepatic TBARS and restored glutathione and catalase activity, reducing oxidative stress. Histopathological investigation demonstrated maintained liver architecture in treated rats. Molecular docking analysis revealed that quercetin and linoleic acid ethyl ester bind strongly to targets of oxidative stress and inflammation, including xanthine oxidoreductase, interleukin\u20106, tumor necrosis factor\u2010\u03b1, and PARP\u20101, suggesting potential hepatoprotective effects. BMF\u2010AE may be a promising natural therapy for oxidative stress\u2010mediated liver injury, according to this study, due to its antioxidant phytoconstituents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71464","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:01:17Z","timestamp":1783364477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatoprotective Effects of\n                    <i>Baccaurea motleyana<\/i>\n                    Fruit Extract Against CCl\n                    <sub>4<\/sub>\n                    \u2010Induced Liver Injury in Rats: In Vivo Evaluation and GC\u2013MS Phytochemical Profiling"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9400-8733","authenticated-orcid":false,"given":"Md. Mahmudul","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safayat Hossen","family":"Momen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momena","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmul Hasan","family":"Eshaque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sohorab","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Southern Mississippi  Hattiesburg Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8850-4689","authenticated-orcid":false,"given":"Tanvir","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"},{"name":"Department of Pharmacy International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ekramul Haque","family":"Ekram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Al","family":"Hafiz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy East West University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Jabir","family":"Rashid","sequence":"additional","affiliation":[{"name":"University of Science &amp; Technology  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7168-3257","authenticated-orcid":false,"given":"S. M. Moazzem","family":"Hossen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41392\u2010024\u201002072\u2010Z;SUBJMETA"},{"key":"e_1_2_14_3_1","unstructured":"2.344Q1SJR Q1; 2.344NAABS NANAABDC NAOfficial Journal of the American College of Gastroenterology| ACGJ Julien T. 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