{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:40Z","timestamp":1785330340818,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Humboldtia<\/jats:italic>\n                    (Fabaceae), an endemic genus of Western Ghats (India), comprises several ecologically and ethnobotanically important species. The present study reports the first comprehensive evaluation of the phytochemical composition and\n                    <jats:italic>in vitro<\/jats:italic>\n                    antioxidant, anti\u2010inflammatory, enzyme inhibition, and cytotoxic potential of\n                    <jats:italic>Humboldtia brunonis<\/jats:italic>\n                    var.\n                    <jats:italic>raktapushpa<\/jats:italic>\n                    , an endemic variety to its type locality. The phytochemical profiling using LC\u2013MS\/MS\u2010QTOF tentatively identified diverse bioactive compounds, predominantly polyphenols, flavonoids, including quinic acid, (\u2212)\u2010epicatechin, asperuloside, chlorogenic acid, vanillic acid, butin, kaempferol, quercetrin, genistein, luteolin, hyperforin, and so forth. The extracts exhibited strong antioxidant activity with low IC\n                    <jats:sub>50<\/jats:sub>\n                    values in DPPH (12.96 \u00b1 0.071\u00a0\u00b5g\/mL) and ABTS (3.79 \u00b1 0.003\u00a0\u00b5g\/mL) assays. Although enzyme inhibitory action was weak, the extract reduced proinflammatory cytokine levels in LPS\u2010induced macrophage cells and showed\n                    <jats:italic>in vitro<\/jats:italic>\n                    cytotoxicity towards the MCF\u20107 cancer cell line. These results highlight its potential for natural product\u2010based drug discovery and thereby conservation of the endemic plant resources.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71466","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:17:14Z","timestamp":1783369034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LC\u2013MS\/MS\u2010QTOF Based Phytochemical Characterization and\n                    <i>In Vitro<\/i>\n                    Pharmacological Potentials of the Endemic Variety,\n                    <i>Humboldtia brunonis<\/i>\n                    var.\n                    <i>raktapushpa<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"C.K.","family":"Sruthi Mohan","sequence":"first","affiliation":[{"name":"Division of Phytochemistry and Pharmacology, Centre for Post Graduate and Research Studies, Department of Botany, St. Joseph's College (Autonomous), Devagiri Affiliated to University of Calicut  Kozhikode Kerala 673008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-7877","authenticated-orcid":false,"given":"Satheesh","family":"George","sequence":"additional","affiliation":[{"name":"Division of Phytochemistry and Pharmacology, Centre for Post Graduate and Research Studies, Department of Botany, St. Joseph's College (Autonomous), Devagiri Affiliated to University of Calicut  Kozhikode Kerala 673008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-1665","authenticated-orcid":false,"given":"Arunaksharan","family":"Narayanankutty","sequence":"additional","affiliation":[{"name":"Division of Cell and Molecular Biology, PG &amp; Research Department of Zoology, St. Joseph's College (Autonomous) Devagiri Affiliated to University of Calicut  Kozhikode Kerala 673008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijpb13010003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u201000114\u2010z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20107847.70902"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2021.100080"},{"key":"e_1_2_10_6_1","first-page":"121","article-title":"A New Variety of Humboldtia (Fabaceae: Caesalpinioideae) From the Western Ghats of India","volume":"1","author":"Udayan P.","year":"2007","journal-title":"Journal of the Botanical Research Institute of Texas"},{"key":"e_1_2_10_7_1","first-page":"406","article-title":"Total Phenolics and Flavonoids in Selected Medicinal Plants From Kerala","volume":"6","author":"John B.","year":"2014","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2013.31211"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073380"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28196875"},{"key":"e_1_2_10_11_1","first-page":"3059","article-title":"In Vitro Antioxidant Activity and Preliminary Phytochemical Analysis of Medicinal Legumes","volume":"5","author":"Kumar J. 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