{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:04:47Z","timestamp":1785330287787,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The global rise of antimicrobial resistance is concomitant with an increasing prevalence of chronic wound infections. Medicinal plants are a promising source of novel therapeutic agents.\n                    <jats:italic>Rubus chamaemorus<\/jats:italic>\n                    , a plant native to Northern Europe traditionally used for wound healing, is one of them. Dried, powdered rhizomes, leaves, and fruits of\n                    <jats:italic>R.\u00a0chamaemorus<\/jats:italic>\n                    were extracted with dichloromethane, methanol, and water. The extracts were screened for antibacterial and antifungal activity. Main compounds were identified using liquid chromatography\u2010mass spectrometry (LC\u2010MS). Biofilm inhibition was assessed using multidrug\u2010resistant\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    . Cytotoxicity against HaCaT cells, inhibition of 5\u2010lipoxygenase (5\u2010LOX) product formation, chelating, and antioxidant properties were determined. While the rhizome and fruit extracts demonstrated no relevant biological activities, the methanolic leaf extract exhibited a low minimal biofilm inhibitory concentration (MBIC = 30\u00a0\u00b5g\/mL) and a potent 5\u2010LOX inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.5 \u00b1 0.5\u00a0\u00b5g\/mL). These properties are likely linked to the pronounced chelating and antioxidant properties of the extract. No cytotoxicity was observed in HaCaT cells and human primary monocytes (up to 200 and 30\u00a0\u00b5g\/mL, respectively). LC\u2010MS analysis of the leaf extracts identified flavonoid glycosides as predominant compounds. These findings support the plant's traditional use in wound healing. Bioactivity\u2010guided fractionation is imperative to identify and characterize the active compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71479","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:53:43Z","timestamp":1783612423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiofilm, Antimicrobial, and Anti\u2010inflammatory Potential of\n                    <i>Rubus chamaemorus<\/i>\n                    Rhizome, Leaf, and Fruit Extracts"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7947-4969","authenticated-orcid":false,"given":"Hildegard","family":"Kieninger","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biology Institute of Pharmacy Partner in the Greifswald Mire Center University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry Institute of Pharmacy University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadin","family":"Schultze","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology Institute of Pharmacy Partner in the Greifswald Mire Center University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Garscha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\/Medicinal Chemistry Institute of Pharmacy University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Guenther","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology Institute of Pharmacy Partner in the Greifswald Mire Center University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology Institute of Pharmacy Partner in the Greifswald Mire Center University of Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"medhochzwei","author":"Storm A.","year":"2024"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2023.0150"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2017.06.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109848"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000377\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524\u2010475X.1996.40404.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.1.20"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010023\u201001121\u20107"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/533452"},{"key":"e_1_2_11_11_1","unstructured":"WHO Bacterial Priority Pathogens List 2024: Bacterial Pathogens of Public Health Importance to Guide Research Development and Strategies to Prevent and Control Antimicrobial Resistance World Health Organization."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.11.010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.145334"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578\u00d70800300319"},{"key":"e_1_2_11_15_1","volume-title":"Native American Ethnobotany","author":"Moerman D. 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