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Response surface methodology (RSM) identified the optimal extraction parameters as follows: extraction time of 147\u00a0min, DES concentration of 42%, and solid\u2010to\u2010liquid ratio of 1:11. Under these conditions, the LEO yield reached 5.11% \u00b1 0.13%, significantly higher than that obtained using pure water. GC\u2013MS analysis indicated that in LEO extracted with DES3, camphor content decreased from 15.2% to 5.69%. In contrast, the levels of linalool and eucalyptol increased markedly. The reduction in ketone content, coupled with substantial enrichment in alcohols and esters, contributed to a notable enhancement in overall LEO quality. Through molecular docking, the interaction mechanisms between DES3 and key LEO components were elucidated. FT\u2010IR spectroscopy was utilized to characterize the formation of hydrogen bonds and the variations of functional groups within DES3. SEM confirmed DES3 disrupted lavender cell walls to fully release aromatic substances and retain volatiles. Pharmacological evaluation verified that optimized LEO exerted potent anti\u2010inflammatory effects by suppressing xylene\u2010triggered ear swelling and inflammatory infiltration in mice. DES\u2010mediated extraction enables targeted component regulation for high\u2010quality LEO, offering a green strategy for sustainable fragrance\u2010pharmaceutical development.<\/jats:p>","DOI":"10.1002\/cbdv.71482","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:11:59Z","timestamp":1785089519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Eutectic Solvents Mediated Optimized Extraction of Lavender Essential Oil: Efficient Camphor Reduction and Bioactivity Assessment"],"prefix":"10.1002","volume":"23","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"China CO\u2010OP Nanjing Institute For Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlu","family":"Hu","sequence":"additional","affiliation":[{"name":"China CO\u2010OP Nanjing Institute For Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Sun","sequence":"additional","affiliation":[{"name":"China CO\u2010OP Nanjing Institute For Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Jiao","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Lavender Conservation and Utilization  Yili China"},{"name":"College of Biological Sciences and Technology Yili Normal University  Yili China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"China CO\u2010OP Nanjing Institute For Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"China CO\u2010OP Nanjing Institute For Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikang","family":"Luo","sequence":"additional","affiliation":[{"name":"China Yili Perilla Beauty Biotechnology Co. Ltd.  Yili China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaode","family":"Huang","sequence":"additional","affiliation":[{"name":"China CO\u2010OP Nanjing Institute For Comprehensive Utilization of Wild Plants  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afres.2023.100335"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.11.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2023.101468"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00289-023-04984-2"},{"issue":"10","key":"e_1_2_11_6_1","article-title":"Refinement and Seperation of Lavender Essential Oil and Its Anti\u2010Inflammatory Activity","volume":"35","author":"Wang Q.","year":"2024","journal-title":"China Food Additives"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.113740"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00280"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.06.041"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1558095"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2012.09.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.46607\/iamj0212102024"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5004\/dwt.2022.29075"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123240"},{"issue":"5","key":"e_1_2_11_15_1","article-title":"Optimization of Subcritical Fluid Extraction Process of Parsley Seeds Essential Oil and Its Component analysis","volume":"34","author":"Zeng Q.","year":"2023","journal-title":"China Food Additives"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jarmap.2024.100538"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11947-024-03643-2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2025.106606"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.144277"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141075"},{"issue":"1","key":"e_1_2_11_21_1","first-page":"1","article-title":"Natural Deep Eutectic Solvent\u2010based Ultrasound\u2010Assisted Extraction of Phenolics From Sunflower Seed Shells: Effects of Roasting and Bioaccessibility Assessment","volume":"60","author":"Melek K.","year":"2025","journal-title":"International Journal of Food Science and Technology"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2025.113303"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja048266j"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131834"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2024.128699"},{"issue":"3","key":"e_1_2_11_26_1","article-title":"Ultrasound\u2010assisted Deep Eutectic Solvent Extraction and AB\u20108 Resin Purification of Polyphenols From Panax Ginseng Leaves: Process Optimization and Antioxidant Enhancement","volume":"378","author":"Chai Y.","year":"2025","journal-title":"Separation and Purification Technology"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-JAALAS-20-000055"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfy132"},{"issue":"5","key":"e_1_2_11_29_1","first-page":"1","article-title":"The Antimicrobial Activity and Essential Oil Constituents of the Leaves and Trunks of Aquilaria Banaensis P.H.Ho\u02c6 (Thymelaeceae) From Vietnam","volume":"38","author":"Thi Y. 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