{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:15Z","timestamp":1785330315956,"version":"3.55.0"},"reference-count":92,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Cirsium boluense<\/jats:italic>\n                    P.H.Davis &amp; Parris (Kartal Kangal\u0131) is a local endemic species in Bolu, T\u00fcrkiye. Members of the\n                    <jats:italic>Cirsium<\/jats:italic>\n                    genus have long been used for cancer, bronchitis, and cough in Anatolia. This study investigated the antimutagenic, antibacterial, and antioxidant properties of methanol extracts obtained from 1st\u00a0year (leaf and root) and 2nd\u00a0year (capitulum, stem, leaf, and root) plant materials, along with total phenolic\u2013flavonoid levels and LC\u2010MS\/MS profiles. Roots from both growth stages and 2nd\u00a0year leaves demonstrated the most effective antimutagenic activity, which may be relevant to traditional uses associated with cancer prevention. The 2nd\u00a0year leaf had the strongest free radical scavenging activity, followed by the capitulum. Leaves showed the highest phenolic\u2013flavonoid content overall. Five bacterial strains were inhibited, with the capitulum showing the most notable antibacterial effect. LC\u2010MS\/MS analysis identified apigenin, chlorogenic acid, 1,5\u2010dicaffeoylquinic acid (cynarin), and luteolin as major phenolics in capitulum and leaves. The findings validate traditional medicinal uses and indicate significant pharmacological and nutraceutical potential for\n                    <jats:italic>C. boluense<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71485","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:40:21Z","timestamp":1785087621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local Endemic\n                    <i>Cirsium boluense<\/i>\n                    : Antimutagenic, Antioxidant, and Antibacterial Activities and Phenolic Profiles of Plant Parts"],"prefix":"10.1002","volume":"23","author":[{"given":"Arzu Ucar","family":"Turker","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science and Art Bolu Abant \u0130zzet Baysal University Bolu T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Necibe Canan","family":"Usta","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Art Tokat Gaziosmanpa\u015fa University Tokat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu Birinci","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Field Crops, Faculty of Agriculture Bolu Abant \u0130zzet Baysal University Bolu T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Eker","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Art Bolu Abant \u0130zzet Baysal University Bolu T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5162-1606","authenticated-orcid":false,"given":"Hakan","family":"Turker","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Art Bolu Abant \u0130zzet Baysal University Bolu T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"376","volume-title":"Flora of Turkey and the East Aegean Islands","author":"Davis P. 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