{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:36Z","timestamp":1785330336258,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004457","name":"The World Academy of Sciences","doi-asserted-by":"publisher","award":["17\u2010362RG\/CHE\/AF\/AC_I\u2010FR3240297747"],"award-info":[{"award-number":["17\u2010362RG\/CHE\/AF\/AC_I\u2010FR3240297747"]}],"id":[{"id":"10.13039\/100004457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The phytochemical investigation of the root barks of\n                    <jats:italic>Croton pseudopulchellus<\/jats:italic>\n                    Pax yielded two new clerodane\u2010type diterpenoids, crotopseudofurans A (\n                    <jats:bold>1<\/jats:bold>\n                    ) and B (\n                    <jats:bold>2<\/jats:bold>\n                    ) along with 14 known compounds (\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>16<\/jats:bold>\n                    ). Compounds\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>3<\/jats:bold>\n                    were obtained as a mixture of C\u201012 epimers. Their structures were established by spectrometric and spectroscopic means, single\u2010crystal x\u2010ray diffraction analysis and by comparison with literature data. The single\u2010crystal x\u2010ray diffraction data of\n                    <jats:bold>5<\/jats:bold>\n                    is reported for the first time. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of plant constituents were determined against Gram\u2010positive and Gram\u2010negative bacteria by using broth microdilution method. The methanol extract and fractions exhibited moderate broad\u2010spectrum activity, with stronger effects against Gram\u2010positive bacteria. Among the isolates, 7,8\u2010dehydrocrotocorylifuran (\n                    <jats:bold>6<\/jats:bold>\n                    ) and vitexin (\n                    <jats:bold>9<\/jats:bold>\n                    ) emerged as the most promising candidates (MIC = 16\u201364\u00a0\u00b5g\/mL) and demonstrated remarkable bactericidal activity against all the tested bacteria. Except compound\n                    <jats:bold>6<\/jats:bold>\n                    , clerodane\u2010type diterpenoids (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    ) showed weak or no activity. The findings support the ethnomedicinal relevance of\n                    <jats:italic>Croton pseudopuchellus<\/jats:italic>\n                    roots and warrant further mechanistic, toxicological and structure\u2013activity relationship studies aimed at developing new antimicrobial agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71493","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:43:21Z","timestamp":1783611801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial Activity of\n                    <i>Ent<\/i>\n                    \u2010Clerodane\u2010Type Diterpenoids and Flavonoids From the Roots of\n                    <i>Croton pseudopulchellus<\/i>\n                    Pax (Euphorbiaceae)"],"prefix":"10.1002","volume":"23","author":[{"given":"Jean III Dazla","family":"Bahanewa","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Sciences University of Maroua  Maroua Cameroon"},{"name":"Natural Product and Environmental Chemistry group (NAPEC) Department of Chemistry Higher Teachers\u2019 Training College University of Maroua  Maroua Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9238-0850","authenticated-orcid":false,"given":"Jo\u00ebl Simplice Ndendoung","family":"Tatsimo","sequence":"additional","affiliation":[{"name":"Natural Product and Environmental Chemistry group (NAPEC) Department of Chemistry Higher Teachers\u2019 Training College University of Maroua  Maroua Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert","family":"Yanda","sequence":"additional","affiliation":[{"name":"Department of Physic and Chemistry Higher Teacher's Training College of Bongor  Bongor Chad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germaine Takongmo","family":"Matsuete","sequence":"additional","affiliation":[{"name":"Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-3746","authenticated-orcid":false,"given":"Peron Bosco","family":"Leutcha","sequence":"additional","affiliation":[{"name":"Natural Product and Environmental Chemistry group (NAPEC) Department of Chemistry Higher Teachers\u2019 Training College University of Maroua  Maroua Cameroon"},{"name":"Department of Chemical Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8088-463X","authenticated-orcid":false,"given":"Jean\u2010De\u2010Dieu","family":"Tamokou","sequence":"additional","affiliation":[{"name":"Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6762-2240","authenticated-orcid":false,"given":"Marco","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio Di","family":"Marco","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Eski\u015fehir Technical University  Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202403377"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114416"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02677"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117352"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3732\/ajb.92.9.1520"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1613399"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092333"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50532007000100002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2012.03.002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.31183\/imcp.2020.00039"},{"key":"e_1_2_11_12_1","unstructured":"H. M.Burkill \u201cFamilies E\u2010I \u201d2(1994) https:\/\/www.cabdirect.org\/cabdirect\/abstract\/19940311397 The Useful Plants of West Tropical Africa."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2017.11.008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2713-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809286-6.00008-X"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.143355"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2024.2405163"},{"key":"e_1_2_11_18_1","unstructured":"Antimicrobial Resistance and Primary Health Care (World Health Organization(World Health Organization 2018) https:\/\/share.google\/FQVD24bvu6r3Zk7id."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.14744\/ejmo.2024.65019"},{"key":"e_1_2_11_20_1","unstructured":"Antibacterial Agents in Clinical Development: an Analysis of the Antibacterial Clinical Development Pipeline(World Health Organization) https:\/\/share.google\/RCbGqmZDuGSDMz5GK."},{"key":"e_1_2_11_21_1","article-title":"Antibacterial and Antioxidant Activities of Isolated Compounds from Prosopis africana Leaves","volume":"1","author":"Yanda L.","year":"2022","journal-title":"International Journal of Analytical Chemistry"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-108857"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2006.02.037"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10102106"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)97976-7"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.062"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574891X11666151105130233"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1723085"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.1783"},{"key":"e_1_2_11_30_1","first-page":"9","article-title":"Phytochemical Study of Algerian Foeniculum vulgare Mill (Apiaceae)","volume":"5","author":"Bousetla A.","year":"2013","journal-title":"Der Pharmacia Lettre"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2017.08.018"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020410"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/p298700000s1"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01237434"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00399a002"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2852(58)90087-0"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053229619010714"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr990324"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0108270187012605"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.586548"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00117-14"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4314\/ijbcs.v3i3.45331"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.106"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.04.025"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.820312"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.02.014"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2016.41"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2975909"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11081014"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NP00137D"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4510"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062455"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053229614024218"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053273314026370"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.04.062"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:26:58Z","timestamp":1785328018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/cbdv.71493"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71493","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71493"}}