{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:30Z","timestamp":1785330330906,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ora\u2010pro\u2010nobis (OPN) is an unconventional food plant rich in polyphenols, but there is a lack of scientific evidence regarding its health benefits and safety, which is concerning, particularly due to its commercialization in nutraceuticals and supplements. This study aimed to evaluate the phenolic profile and\n                    <jats:italic>in vitro<\/jats:italic>\n                    bioactivities of extracts from the leaves, fruits, and flowers of OPN. Phenolic composition and\n                    <jats:italic>in vitro<\/jats:italic>\n                    antioxidant, antimalarial, cytotoxic, and antihemolytic potential were evaluated. Rutin and ellagic acid were the primary compounds. The flower extract was the richest in polyphenols and exhibited the greatest chemical antioxidant activity. The samples inhibited lipoperoxidation and NO generation in a dose\u2010dependent manner, and exhibited low cytotoxicity in normal and cancer cells, cellular antioxidant effects, and antimalarial potential. OPN leaves and flowers may be suitable for developing formulations with antioxidant, antihemolytic, and antimalarial potential; however,\n                    <jats:italic>in vivo<\/jats:italic>\n                    assays are required to confirm these properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71496","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:53:31Z","timestamp":1783497211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Phenolic Composition, Antioxidant, Antimalarial, and Erythroprotective Activities of Leaves, Flowers, and Fruits of Ora\u2010pro\u2010nobis (\n                    <i>Pereskia aculeata<\/i>\n                    )"],"prefix":"10.1002","volume":"23","author":[{"given":"Thiago Mendanha","family":"Cruz","sequence":"first","affiliation":[{"name":"Graduation Program in Chemistry State University of Ponta Grossa  Ponta Grossa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda dos Santos","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicological Analysis In Vitro and In Vivo Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Stelle","sequence":"additional","affiliation":[{"name":"Graduation Program in Chemistry State University of Ponta Grossa  Ponta Grossa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaise Caputo","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicological Analysis In Vitro and In Vivo Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Alves","family":"Bento","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicological Analysis In Vitro and In Vivo Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional and Toxicological Analysis In Vitro and In Vivo Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-1597","authenticated-orcid":false,"given":"Daniel","family":"Granato","sequence":"additional","affiliation":[{"name":"School of Science \u2010 Faculty of Health and Environmental Sciences Auckland University of Technology  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariza Boscacci","family":"Marques","sequence":"additional","affiliation":[{"name":"Graduation Program in Chemistry State University of Ponta Grossa  Ponta Grossa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2024.101116"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114643"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c05652"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-014-0423-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.112042"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.14808\/sci.plena.2021.051503"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09583157.2023.2214342"},{"key":"e_1_2_9_9_1","unstructured":"H. I. S. C.Hawaii \u201cBarbados Gooseberry (Pereskia aculeata) \u201d Can be found under:https:\/\/dlnr.hawaii.gov\/hisc\/info\/invasive\u2010species\u2010profiles\/barbados\u2010gooseberry\/(2022)."},{"key":"e_1_2_9_10_1","unstructured":"A. N. D. V. 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