{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:42Z","timestamp":1785330342348,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    By using the naphthalene group\u2010containing \u03b2\u2010diketone ligand and 5\u2010nitro\u20101,10\u2010phenanthroline, three novel heteroleptic eight\u2010coordinate complexes of Eu(III), Tb(III), and Gd(III) have been synthesized. Methods such as elemental analysis, MALDI TOF\u2010MS, UV\u2010Vis, and FT\u2010IR were used to determine the structural characterization of these compounds. The photoluminescent characteristics of the synthesized complexes of Eu(III), Tb(III), and Gd(III) were further investigated. The ligand (L\n                    <jats:sub>1<\/jats:sub>\n                    ) and co\u2010ligand 5\u2010nitro\u20101,10\u2010phenanthroline (L\n                    <jats:sub>2<\/jats:sub>\n                    ) and its three lanthanide complexes [Eu(L\n                    <jats:sub>1<\/jats:sub>\n                    )\n                    <jats:sub>3<\/jats:sub>\n                    (L\n                    <jats:sub>2<\/jats:sub>\n                    )]\u00b73H\n                    <jats:sub>2<\/jats:sub>\n                    O, [Tb(L\n                    <jats:sub>1<\/jats:sub>\n                    )\n                    <jats:sub>3<\/jats:sub>\n                    (L\n                    <jats:sub>2<\/jats:sub>\n                    )], and [Gd(L\n                    <jats:sub>1<\/jats:sub>\n                    )\n                    <jats:sub>3<\/jats:sub>\n                    (L\n                    <jats:sub>2<\/jats:sub>\n                    )] were tested in human breast (MCF\u20107), colon (DLD\u20101), and lung (A549) cancer cell lines for 72\u00a0h. Furthermore, these compounds were screened in a human embryonic kidney cell line (HEK\u2010293T) for cytotoxicity. The results demonstrated that these compounds have antiproliferative activity in three cancer cell lines with low IC\n                    <jats:sub>50<\/jats:sub>\n                    values. The probable mode of action for the cytotoxic effect was explored through molecular modeling. Previous studies reported epidermal growth factor receptor (EGFR)\u2010inhibiting potential for compounds with similar scaffolds. The docking study demonstrated that the three chelates would have the potential to bind to the EGFR structure. The molecular dynamics (MD) simulation study consolidated this finding as the complex structures were found to be stable with some differences. MMPBSA (molecular mechanics with Poisson\u2013Boltzmann and surface area solvation) energy calculation results also showed high binding affinities for the chelates.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71502","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:29:48Z","timestamp":1784129388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eu(III), Tb(III), and Gd(III) Complexes With Dual Ligand Architecture: Synthesis, Characterization, Photoluminescence, Cytotoxic, and Molecular Docking Studies"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-7968","authenticated-orcid":false,"given":"Ahmet Oral","family":"Sar\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies, Naci Top\u00e7uo\u011flu Vocational School Gaziantep University  Gaziantep T\u00fcrkiye"},{"name":"Ulu\u011f Bey High Technology Application and Research Center (ULUTEM) Gaziantep University  Gaziantep T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-8131","authenticated-orcid":false,"given":"Hatice Gamze","family":"Sogukomerogullari","sequence":"additional","affiliation":[{"name":"Ulu\u011f Bey High Technology Application and Research Center (ULUTEM) Gaziantep University  Gaziantep T\u00fcrkiye"},{"name":"Medical Services and Techniques Department, Vocational School of Health Services Gaziantep University  Gaziantep T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-5271","authenticated-orcid":false,"given":"Muhammed Tilahun","family":"Muhammed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Suleyman Demirel University  Isparta 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