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To identify more effective anti\u2010inflammatory compound, 22 novel hesperidin derivatives incorporating fatty and cinnamic acid groups were designed and synthesized. Among them, compound\n                    <jats:bold>B8<\/jats:bold>\n                    demonstrated the most potent inhibitory effect against LPS\u2010induced NO production in RAW264.7 macrophages (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a010.4\u00a0\u00b1\u00a00.7\u00a0\u00b5M) with no significant cytotoxicity. Molecular docking with the NLRP3 protein demonstrated a favorable binding energy of \u22128.39 kcal\/mol, while quantum chemical calculations provided insights into the interaction. These results provide a valuable structural design strategy for advancing the development of new hesperidin anti\u2010inflammatory leads.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71506","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:25:26Z","timestamp":1784085926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Synthesis of Hesperidin Derivatives With Anti\u2010Inflammatory Potential"],"prefix":"10.1002","volume":"23","author":[{"given":"Hong\u2010Yue","family":"Ma","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical Sciences China Three Gorges University  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical Sciences China Three Gorges University  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wei","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical Sciences China Three Gorges University  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical Sciences China Three Gorges University  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical Sciences China Three Gorges University  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ran","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical Sciences China Three Gorges University  Yichang China"},{"name":"Yichang Municipal Key Laboratory for High\u2010Value Utilization of Citrus China Three Gorges University  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Natural Products Research and Development College of Biological and Pharmaceutical Sciences China Three Gorges University  Yichang China"},{"name":"Yichang Municipal Key Laboratory for High\u2010Value Utilization of Citrus China Three Gorges University  Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chang","sequence":"additional","affiliation":[{"name":"Angel Yeast Co. 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