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Compound\n                    <jats:bold>1<\/jats:bold>\n                    possesses a three\u2010membered epoxide ring at C\u201012 and C\u201013. The planar structure and absolute configuration of\n                    <jats:bold>1<\/jats:bold>\n                    were elucidated by comprehensive spectroscopic analyses. The inhibitory effects of compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2010\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    on lactate dehydrogenase (LDH) release in J774A.1 cell was evaluated. The results indicated that compound\n                    <jats:bold>1<\/jats:bold>\n                    exhibited significant anti\u2010inflammatory activity, with an inhibitory concentration 50% (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) value of 3.30 \u00b1 0.47 \u00b5M on LDH release and reduced the Interleukin 1\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) levels in a dose\u2010dependent manner.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71515","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:52:42Z","timestamp":1785088362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nudiloid Z, a New Labdane\u2010Type Diterpenoid From\n                    <i>Callicarpa nudiflora<\/i>\n                    With Anti\u2010Inflammatory Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"},{"name":"Southwest United Graduate School Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ling","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Ting","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Aurang","family":"Zeb","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Zi","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"},{"name":"Southwest United Graduate School Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Lin","family":"Kong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Dan","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Li","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco\u2010Security, School of Pharmacy, School of Chemical Science and Technology Yunnan University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction 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