{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:05:25Z","timestamp":1785330325276,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The genus Eugenia comprises approximately 1050 species widely used in traditional medicine and human nutrition due to their diverse pharmacological properties. This review aimed to critically summarize the anticancer potential of Eugenia species and to correlate their biological activities with the presence of bioactive phytochemicals. Literature published between 2013 and 2025 was retrieved from PubMed, SciELO, and Google Scholar databases using terms related to Eugenia, cancer, antiproliferative, and cytotoxic activities. Increasing evidence has demonstrated the anticancer effects of selected Eugenia species in in silico, in vitro, and in vivo models against different cancer types. These effects are associated with multiple mechanisms, including apoptosis induction via caspase\u20103\/7 activation and Fas receptor upregulation, inhibition of tumor cell migration and invasion through suppression of MMP\u20102 and MMP\u20109, and cell cycle arrest. The observed activities are closely related to the presence of flavonoids, phenolic acids, carotenoids, monoterpenes, triterpenes, and sesquiterpenes. Despite promising preclinical findings, limitations such as the scarcity of in vivo studies, lack of extract standardization, and absence of clinical trials still hinder the translational application of Eugenia\u2010derived compounds in oncology. Future studies focusing on mechanistic elucidation, bioavailability, toxicity, and clinical validation are essential for the development of Eugenia\u2010based anticancer therapies.<\/jats:p>","DOI":"10.1002\/cbdv.71517","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:41:46Z","timestamp":1785087706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nature's Hidden Arsenal: Unveiling the Anticancer Potential of\n                    <i>Eugenia<\/i>\n                    Species"],"prefix":"10.1002","volume":"23","author":[{"given":"Mariana Toledo Martins","family":"Pereira","sequence":"first","affiliation":[{"name":"Research Laboratory on Natural Products and Bioactive Molecules Health Institute Federal Fluminense University  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Sardou","family":"Charret","sequence":"additional","affiliation":[{"name":"Research Laboratory on Natural Products and Bioactive Molecules Health Institute Federal Fluminense University  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Cesar","family":"Thurler\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Research Laboratory on Natural Products and Bioactive Molecules Health Institute Federal Fluminense University  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"Biotechnological Postgraduate Program Tiradentes University  Aracaju Sergipe Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"UCD School of Chemical and Bioprocess Engineering University College Dublin  Belfield Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius D'Avila Bitencourt","family":"Pascoal","sequence":"additional","affiliation":[{"name":"Research Laboratory on Natural Products and Bioactive Molecules Health Institute Federal Fluminense University  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aislan Cristina Rheder Fagundes","family":"Pascoal","sequence":"additional","affiliation":[{"name":"Research Laboratory on Natural Products and Bioactive Molecules Health Institute Federal Fluminense University  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.03.018"},{"key":"e_1_2_8_3_1","unstructured":"Flora do Brasil.Flora do Brasil\u2014Jardim Bot\u00e2nico do Rio de Janeiro https:\/\/floradobrasil.jbrj.gov.br\/FB10338(accessed on November 17 2024)."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0656-7262"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10081155"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_8_7_1","volume-title":"Global Cancer Observatory (GCO)","author":"International Agency for Research on Cancer (IARC)"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11192\u2010009\u20100146\u20103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.2981"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/pm.pm_16_17"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/AABC.S217205"},{"key":"e_1_2_8_12_1","first-page":"3551","article-title":"Apoptosis\u2010mediated Antiproliferation of A549 Lung Cancer Cells by Chalcone From Eugenia aquea and Molecular Docking Simulation","volume":"19","author":"Hadisaputri Y. E.","year":"2020","journal-title":"Oncology Letters"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.33448\/rsd\u2010v12i3.40536"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500429"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101876"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111736"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1261343"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines4030051"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000937"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109615"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-020-00123-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8030029"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.31083\/ph.2016.5747"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X21996156","article-title":"Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils","volume":"16","author":"Jer\u00f4nimo L. B.","year":"2021","journal-title":"Natural Products Communications"},{"key":"e_1_2_8_25_1","first-page":"1139","article-title":"Essential Oils From Eugenia punicifolia Aerial Parts: Chemical Composition and Antiproliferative Activity","volume":"32","author":"Fernandes Y. M. L.","year":"2021","journal-title":"Journal of the Brazilian Chemical Society"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200114"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300893n"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16172929"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants14111671"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.10.006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2019-11-1-81-90"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201600089"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902018000217267"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.12.011"},{"key":"e_1_2_8_35_1","first-page":"367","article-title":"Eugenia Uniflora Active Fraction Inhibits Dalton Lymphoma Ascites in Mice","volume":"8","author":"Syama S.","year":"2019","journal-title":"International Journal of Engineering Research & Technology"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26030740"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2022.2153128"},{"key":"e_1_2_8_38_1","first-page":"4297","article-title":"Phenolic Compounds in Eugenia Uniflora Leaves and Cytotoxic Activity","volume":"38","author":"Oliveira G. F. M.","year":"2023","journal-title":"Natural Product Research"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18081199"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-816814-1.00018-1"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.01.012"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803138-4.00044-7"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443404"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1529"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00245"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093233"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11041321"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040762"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u201040422007000200026"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:25:53Z","timestamp":1785327953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/cbdv.71517"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71517","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71517"}}